LOCUS HUMHBB 73308 bp DNA PRI 18-FEB-1994 DEFINITION Human beta globin region on chromosome 11. ACCESSION U01317 J00179 J00093 J00094 J00096 J00158 J00159 J00160 J00161 J00162 J00163 J00164 J00165 J00166 J00167 J00168 J00169 J00170 J00171 J00172 J00173 J00174 J00175 J00177 J00178 K01239 K01890 K02544 M18047 M19067 M24868 M24886 X00423 X00424 X00672 NID g455025 VERSION U01317.1 GI:455025 KEYWORDS Alu repeat; HPFH; KpnI repetitive sequence; RNA polymerase III; allelic variation; alternate cap site; beta-1 pseudogene; beta-globin; delta-globin; epsilon-globin; gamma-globin; gene duplication; globin; polymorphism; promoter mutation; pseudogene; repetitive sequence; thalassemia. SOURCE Human mRNA, cDNA and DNA. ORGANISM Homo sapiens Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Mammalia; Eutheria; Primates; Catarrhini; Hominidae; Homo. REFERENCE 1 (bases 62409 to 62631; 63482 to 63610) AUTHORS Marotta,C.A., Forget,B.G., Weissman,S.M., Verma,I.M., McCaffrey,R.P. and Baltimore,D. TITLE Nucleotide sequences of human globin messenger RNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 71, 2300-2304 (1974) MEDLINE 74275150 REFERENCE 2 (bases 63602 to 63646) AUTHORS Forget,B.G., Marotta,C.A., Weissman,S.M. and Cohen-Solal,M.M. TITLE Nucleotide sequences of the 3'-terminal untranslated region of messenger RNA for human beta globin chain JOURNAL Proc. Natl. Acad. Sci. U.S.A. 72, 3614-3618 (1975) MEDLINE 76053173 REFERENCE 3 (bases 63593 to 63626) AUTHORS Proudfoot,N.J. and Brownlee,G.G. TITLE Nucleotide sequences of globin messenger RNA JOURNAL Br. Med. Bull. 32, 251-256 (1976) MEDLINE 77022845 REFERENCE 4 (bases 63673 to 63743) AUTHORS Proudfoot,N.J. and Longley,J.I. TITLE The 3' terminal sequences of human alpha and beta globin messenger RNAs: Comparison with rabbit globin messenger RNA JOURNAL Cell 9, 733-746 (1976) MEDLINE 77114153 REFERENCE 5 (sites) AUTHORS Proudfoot,N.J. and Brownlee,G.G. TITLE Non-coding region sequences in eukaryotic messenger RNA JOURNAL Nature 263, 211-214 (1976) MEDLINE 76267786 REFERENCE 6 (bases 63596 to 63743) AUTHORS Proudfoot,N.J. TITLE Complete 3' noncoding region sequences of rabbit and human beta-globin messenger RNA's JOURNAL Cell 10, 559-570 (1977) MEDLINE 77183598 REFERENCE 7 (bases 62137 to 62193) AUTHORS Baralle,F.E. TITLE Complete nucleotide sequence of the 5' noncoding region of human alpha- and beta-globin mRNA JOURNAL Cell 12, 1085-1095 (1977) MEDLINE 78082246 REFERENCE 8 (sites) AUTHORS Marotta,C.A., Forget,B.G., Cohen-Solal,M.M., Wilson,J.T. and Weissman,S.M. TITLE Human beta-globin messenger RNA: I. Nucleotide sequences derived from complementary RNA JOURNAL J. Biol. Chem. 252, 5019-5031 (1977) MEDLINE 77207122 REFERENCE 9 (bases 62187 to 63610) AUTHORS Cohen-Solal,M.M., Forget,B.G., Prensky,W., Marotta,C.A. and Weissman,S.M. TITLE Human beta-globin messenger RNA: II. Nucleotide sequences derived from 125-I-labeled globin messenger RNA JOURNAL J. Biol. Chem. 252, 5032-5039 (1977) MEDLINE 77207123 REFERENCE 10 (bases 54790 to 54881; 62409 to 62631; 63482 to 63715) AUTHORS Marotta,C.A., Wilson,J.T., Forget,B.G. and Weissman,S.M. TITLE Human beta-globin messenger RNA. III. Nucleotide sequences derived from complementary DNA JOURNAL J. Biol. Chem. 252, 5040-5053 (1977) MEDLINE 77207124 REFERENCE 11 (bases 62137 to 62189) AUTHORS Chang,J.C., Temple,G.F., Poon,R., Neumann,K.H. and Kan,Y.W. TITLE The nucleotide sequences of the untranslated 5' regions of human alpha- and beta-globin mRNAs JOURNAL Proc. Natl. Acad. Sci. U.S.A. 74, 5145-5149 (1977) MEDLINE 78053067 REFERENCE 12 (bases 56103 to 56184) AUTHORS Lawn,R.M., Fritsch,E.F., Parker,R.C., Blake,G. and Maniatis,T. TITLE The isolation and characterization of linked delta- and beta-globin genes from a library of human DNA JOURNAL Cell 15, 1157-1174 (1978) MEDLINE 79084172 REFERENCE 13 (bases 35854 to 35946; 63482 to 63531) AUTHORS Little,P., Curtis,P., Coutelle,C., van den Berg,J., Dalgleish,R., Malcolm,S., Courtney,M., Westaway,D. and Williamson,R. TITLE Isolation and partial sequence of recombinant plasmids containing human alpha-, beta- and gamma-globin cDNA fragments JOURNAL Nature 273, 640-643 (1978) MEDLINE 78199818 REFERENCE 14 (bases 62187 to 63742) AUTHORS Wilson,J.T., Wilson,L.B., DeRiel,J.K., Villa-Komaroff,L., Efstratiadis,A., Forget,B.G. and Weissman,S.M. TITLE Insertion of synthetic copies of human globin genes into bacterial plasmids JOURNAL Nucleic Acids Res. 5, 563-581 (1978) MEDLINE 78136643 REFERENCE 15 (bases 34478 to 34563; 39414 to 39499) AUTHORS Chang,J.C., Poon,R., Neumann,K.H. and Kan,Y.W. TITLE The nucleotide sequence of the 5' untranslated region of human gamma-globin mRNA JOURNAL Nucleic Acids Res. 5, 3515-3522 (1978) MEDLINE 79074234 REFERENCE 16 (bases 40839 to 40985) AUTHORS Poon,R., Wai,K.Y. and Boyer,H.W. TITLE Sequence of the 3' noncoding and adjacent regions of human gamma-globin mRNA JOURNAL Nucleic Acids Res. 5, 4625-4630 (1978) MEDLINE 79136489 REFERENCE 17 (bases 35826 to 35907; 40742 to 40823) AUTHORS Smithies,O., Blechl,A.E., Denniston-Thompson,K., Newell,N., Richards,J.E., Slightom,J.L., Tucker,P.W. and Blattner,F.R. TITLE Cloning human fetal gamma globin and mouse alpha-type globin DNA: Characterization and partial sequencing JOURNAL Science 202, 1284-1289 (1978) MEDLINE 79076620 REFERENCE 18 (bases 34478 to 34536; 62137 to 62192; 63608 to 63742) AUTHORS Kan,Y.W., Chang,C.S. and Poon,R. TITLE Nucleotide sequences of the untranslated 5' and 3' regions of human alpha-, beta-, and gamma-globin mRNAS JOURNAL (in) Stamatoyannopoulos,G. and Newhouse,A.W. (Eds.); CELLULAR AND MOLECULAR REGULATION OF HEMOGLOBIN SWITCHING: 0-0; Grune and Stratton, New York (1979) In press REFERENCE 19 (sites) AUTHORS Chang,J.C. and Kan,Y.W. TITLE Beta-0 thalassemia, a nonsense mutation in man JOURNAL Proc. Natl. Acad. Sci. U.S.A. 76, 2886-2889 (1979) MEDLINE 79223894 REFERENCE 20 (bases 19846 to 19965) AUTHORS Proudfoot,N.J. and Baralle,F.E. TITLE Molecular cloning of human epsilon-globin gene JOURNAL Proc. Natl. Acad. Sci. U.S.A. 76, 5435-5439 (1979) MEDLINE 80101437 REFERENCE 21 (sites) AUTHORS Chang,J.C., Kan,Y.W., Trecartin,R.F. and Temple,G.F. TITLE Nonsense mutation as a cause of beta-0 thalassemia JOURNAL Ann. N. Y. Acad. Sci. 344, 113-119 (1980) MEDLINE 80240390 REFERENCE 22 (sites) AUTHORS Fritsch,E.F., Lawn,R.M. and Maniatis,T. TITLE Molecular cloning and characterization of the human beta-like globin gene cluster JOURNAL Cell 19, 959-972 (1980) MEDLINE 80199924 REFERENCE 23 (bases 19462 to 21741) AUTHORS Baralle,F.E., Shoulders,C.C. and Proudfoot,N.J. TITLE The primary structure of the human epsilon-globin gene JOURNAL Cell 21, 621-626 (1980) MEDLINE 81064664 REFERENCE 24 (bases 34422 to 36069; 39358 to 40986) AUTHORS Slightom,J.L., Blechl,A.E. and Smithies,O. TITLE Human fetal G-gamma and A-gamma globin genes: complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes JOURNAL Cell 21, 627-638 (1980) MEDLINE 81064665 REFERENCE 25 (bases 54618 to 56602) AUTHORS Spritz,R.A., DeRiel,J.K., Forget,B.G. and Weissman,S.M. TITLE Complete nucleotide sequence of the human delta-globin gene JOURNAL Cell 21, 639-646 (1980) MEDLINE 81064666 REFERENCE 26 (bases 62034 to 64083) AUTHORS Lawn,R.M., Efstratiadis,A., O'Connell,C. and Maniatis,T. TITLE The nucleotide sequence of the human beta-globin gene JOURNAL Cell 21, 647-651 (1980) MEDLINE 81064667 REFERENCE 27 (sites) AUTHORS Efstratiadis,A., Posakony,J.W., Maniatis,T., Lawn,R.M., O'Connell,C., Spritz,R.A., DeRiel,J.K., Forget,B.G., Weissman,S.M., Slightom,J.L., Blechl,A.E., Smithies,O., Baralle,F.E., Shoulders,C.C. and Proudfoot,N.J. TITLE The structure and evolution of the human beta-globin gene family JOURNAL Cell 21, 653-668 (1980) MEDLINE 81064668 REFERENCE 28 (bases 19864 to 19983) AUTHORS Baralle,F.E., Shoulders,C.C., Goodbourn,S., Jeffreys,A. and Proudfoot,N.J. TITLE The 5' flanking region of human epsilon-globin gene JOURNAL Nucleic Acids Res. 8, 4393-4404 (1980) MEDLINE 81053776 REFERENCE 29 (bases 32353 to 43728) AUTHORS Shen,S.-H.H., Slightom,J.L. and Smithies,O. TITLE A history of the human fetal globin gene duplication JOURNAL Cell 26, 191-203 (1981) MEDLINE 82137053 REFERENCE 30 (sites) AUTHORS Busslinger,M., Moschonas,N. and Flavell,R.A. TITLE +beta thalassemia: Aberrant splicing results from a single point mutation in an intron JOURNAL Cell 27, 289-298 (1981) MEDLINE 82137068 REFERENCE 31 (bases 32353 to 33218; 51978 to 52472) AUTHORS Duncan,C.H., Jagadeeswaran,P., Wang,R.R. and Weissman,S.M. TITLE Structural analysis of templates and RNA polymerase III transcripts of Alu family sequences interspersed among the human beta-like globin genes JOURNAL Gene 13, 185-196 (1981) MEDLINE 81213477 REFERENCE 32 (sites) AUTHORS Orkin,S.H. and Goff,S.C. TITLE Nonsense and frameshift mutations in beta-0-thalassemia detected in cloned beta-globin genes JOURNAL J. Biol. Chem. 256, 9782-9784 (1981) MEDLINE 82007799 REFERENCE 33 (bases 62454 to 62613) AUTHORS Orkin,S.H., Goff,S.C. and Nathan,D.G. TITLE Heterogeneity of DNA deletion in gamma-delta-beta-thalassemia JOURNAL J. Clin. Invest. 67, 878-884 (1981) MEDLINE 81142681 REFERENCE 34 (sites) AUTHORS Trecartin,R.F., Liebhaber,S.A., Chang,J.C., Lee,K.Y., Kan,Y.W., Furbetta,M., Angius,A. and Cao,A. TITLE Beta-0 thalassemia in Sardinia is caused by a nonsense mutation JOURNAL J. Clin. Invest. 68, 1012-1017 (1981) MEDLINE 82031272 REFERENCE 35 (sites) AUTHORS Westaway,D. and Williamson,R. TITLE An intron nucleotide sequence variant in a cloned beta-plus-thalassemia globin gene JOURNAL Nucleic Acids Res. 9, 1777-1787 (1981) MEDLINE 81222902 REFERENCE 36 (sites) AUTHORS Moschonas,N., de Boer,E., Grosveld,F.G., Dahl,H.-H.M., Wright,S., Shewmaker,C.K. and Flavell,R.A. TITLE Structure and expression of a cloned beta-0 thalassemic globin gene JOURNAL Nucleic Acids Res. 9, 4391-4401 (1981) MEDLINE 82059470 REFERENCE 37 (bases 60489 to 60948) AUTHORS Spritz,R.A. TITLE Duplication/deletion polymorphism 5'- to the human beta globin gene JOURNAL Nucleic Acids Res. 9, 5037-5047 (1981) MEDLINE 82081827 REFERENCE 38 (bases 59345 to 59593) AUTHORS Miesfeld,R., Krystal,M. and Arnheim,N. TITLE A member of a new repeated sequence family which is conserved throughout eukaryotic evolution is found between the human delta and beta globin genes JOURNAL Nucleic Acids Res. 9, 5931-5947 (1981) MEDLINE 82081870 REFERENCE 39 (bases 16595 to 17840) AUTHORS Di Segni,G., Carrara,G., Tocchini-Valentini,G.R., Shoulders,C.C. and Baralle,F.E. TITLE Selective in vitro transcription of one of the two Alu family repeats present in the 5' flanking region of the human epsilon-globin gene JOURNAL Nucleic Acids Res. 9, 6709-6722 (1981) MEDLINE 82150261 REFERENCE 40 (sites) AUTHORS Adams,J.G.III., Steinberg,M.H., Newman,M.V., Morrison,W.T., Benz,E.J.Jr.. and Iyer,R. TITLE Beta-thalassemia present in cis to a new beta-chain structural variant, Hb Vicksburg [beta75(e19)leu->0] JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78, 469-473 (1981) MEDLINE 81223760 REFERENCE 41 (bases 61921 to 63824) AUTHORS Spritz,R.A., Jagadeeswaran,P., Choudary,P.V., Biro,P.A., Elder,J.T., DeRiel,J.K., Manley,J.L., Gefter,M.L., Forget,B.G. and Weissman,S.M. TITLE Base substitution in an intervening sequence of a beta-plus-thalassemic human globin gene JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78, 2455-2459 (1981) MEDLINE 81223897 REFERENCE 42 (sites) AUTHORS Baird,M., Driscoll,C., Schreiner,H., Sciarratta,G.V., Sansone,G., Niazi,G., Ramirez,F. and Bank,A. TITLE A nucleotide change at a splice junction in the human beta-globin gene is associated with beta-0-thalassemia JOURNAL Proc. Natl. Acad. Sci. U.S.A. 78, 4218-4221 (1981) MEDLINE 82037810 REFERENCE 43 (sites) AUTHORS Grosveld,F., Busslinger,M., Grosveld,G., Groffen,J., DeKleine,A. and Flavell,R.A. TITLE The structure and expression of the haemoglobin genes JOURNAL Adv. Exp. Med. Biol. 158, 65-80 (1982) MEDLINE 83123533 REFERENCE 44 (sites) AUTHORS Treisman,R., Proudfoot,N.J., Shander,M. and Maniatis,T. TITLE A single-base change at a splice site in a 0-beta-thalassemic gene causes abnormal RNA splicing JOURNAL Cell 29, 903-911 (1982) MEDLINE 83103118 REFERENCE 45 (bases 63823 to 64083) AUTHORS Poncz,M., Ballantine,M., Solowiejczyk,D., Barak,I., Schwartz,E. and Surrey,S. TITLE Beta-thalassemia in a Kurdish Jew: Single base changes in the T-A-T-A box JOURNAL J. Biol. Chem. 257, 5994-5996 (1982) MEDLINE 82189953 REFERENCE 46 (bases 61873 to 62198; 62375 to 62448) AUTHORS Gorski,J., Fiori,M. and Mach,B. TITLE A new nonsense mutation as the molecular basis for beta-0 thalassemia JOURNAL J. Mol. Biol. 154, 537-540 (1982) MEDLINE 82192422 REFERENCE 47 (bases 50716 to 51215) AUTHORS Jagadeeswaran,P., Tuan,D., Forget,B.G. and Weissman,S.M. TITLE A gene deletion ending at the midpoint of a repetitive DNA sequence in one form of hereditary persistence of fetal haemoglobin JOURNAL Nature 296, 469-470 (1982) MEDLINE 82148648 REFERENCE 48 (sites) AUTHORS Orkin,S.H., Kazazian,H.H.Jr.., Antonarakis,S.E., Goff,S.C., Boehm,C.D., Sexton,J.P., Waber,P.G. and Giardina,P.J. TITLE Linkage of beta-thalassemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster JOURNAL Nature 296, 627-631 (1982) MEDLINE 82173174 REFERENCE 49 (sites) AUTHORS Ottolenghi,S. and Giglioni,B. TITLE The deletion in a type of delta-0-beta-0-thalassemia begins in an inverted AluI repeat JOURNAL Nature 300, 770-771 (1982) MEDLINE 83089008 REFERENCE 50 (bases 62651 to 62715) AUTHORS Spence,S.E., Pergolizzi,R.G., Donovan-Peluso,M., Kosche,K.A., Dobkin,C.S. and Bank,A. TITLE Five nucleotide changes in the large intervening sequence of a beta globin gene in a beta-plus thalassemia patient JOURNAL Nucleic Acids Res. 10, 1283-1294 (1982) MEDLINE 82174308 REFERENCE 51 (bases 60676 to 62137) AUTHORS Moschonas,N., de Boer,E. and Flavell,R.A. TITLE The DNA sequence of the 5' flanking region of the human beta-globin gene: Evolutionary conservation and polymorphic differences JOURNAL Nucleic Acids Res. 10, 2109-2120 (1982) MEDLINE 82196882 REFERENCE 52 (sites) AUTHORS Allan,M., Grindlay,G.J., Stefani,L. and Paul,J. TITLE Epsilon globin gene transcripts originating upstream of the mRNA cap site in K562 cells and normal human embryos JOURNAL Nucleic Acids Res. 10, 5133-5147 (1982) MEDLINE 83064468 REFERENCE 53 (sites) AUTHORS Kinniburgh,A.J., Maquat,L.E., Schedl,T., Rachmilewitz,E. and Ross,J. TITLE mRNA-deficient beta-0-thalassemia results from a single nucleotide deletion JOURNAL Nucleic Acids Res. 10, 5421-5427 (1982) MEDLINE 83064490 REFERENCE 54 (bases 54438 to 54740) AUTHORS Kimura,A., Matsunaga,E., Ohta,Y., Fujiyoshi,T., Matsuo,T., Nakamura,T., Imamura,T., Yanase,T. and Takagi,Y. TITLE Structure of cloned delta-globin genes from a normal subject and a patient with delta-thalassemia; sequence polymorphisms found in the delta-globin gene region of Japanese individuals JOURNAL Nucleic Acids Res. 10, 5725-5732 (1982) MEDLINE 83064512 REFERENCE 55 (bases 10410 to 13774) AUTHORS Shen,S.-H.H. and Smithies,O. TITLE Human globin pseudo-beta-2 is not a globin-related sequence JOURNAL Nucleic Acids Res. 10, 7809-7818 (1982) MEDLINE 83116993 REFERENCE 56 (sites) AUTHORS Spritz,R.A. and Orkin,S.H. TITLE Duplication followed by deletion accounts for the structure of an Indian deletion beta-0-thalassemia gene JOURNAL Nucleic Acids Res. 10, 8025-8029 (1982) MEDLINE 83143274 REFERENCE 57 (bases 62373 to 62421) AUTHORS Flavell,R.A., Bud,H., Bullman,H., Busslinger,M., de Boer,E., de Kleine,A., Golden,L., Groffen,J., Grosveld,F.G., Mellor,A.L., Moschonas,N. and Weiss,E. TITLE The structure and expression of mammalian gene clusters JOURNAL Prog. Clin. Biol. Res. 103, 37-55 (1982) MEDLINE 83144268 REFERENCE 58 (sites) AUTHORS Ley,T.J. and Nienhuis,A.W. TITLE A weak upstream promoter gives rise to long human beta-globin RNA molecules JOURNAL Biochem. Biophys. Res. Commun. 112, 1041-1048 (1983) MEDLINE 83204146 REFERENCE 59 (sites) AUTHORS Carlson,D.P. and Ross,J. TITLE Human beta-globin promoter and coding sequences transcribed by RNA polymerase III JOURNAL Cell 34, 857-864 (1983) MEDLINE 84026491 REFERENCE 60 (sites) AUTHORS Allan,M., Lanyon,W.G. and Paul,J. TITLE Multiple origins of transcription in the 4.5 kb upstream of the epsilon-globin gene JOURNAL Cell 35, 187-197 (1983) MEDLINE 84026517 REFERENCE 61 (sites) AUTHORS Vanin,E.F., Henthorn,P.S., Kioussis,D., Grosveld,F. and Smithies,O. TITLE Unexpected relationships between four large deletions in the human beta-globin gene cluster JOURNAL Cell 35, 701-709 (1983) MEDLINE 84082096 REFERENCE 62 (bases 50744 to 67204) AUTHORS Poncz,M., Schwartz,E., Ballantine,M. and Surrey,S. TITLE Nucleotide sequence analysis of the delta-beta-globin gene region in humans JOURNAL J. Biol. Chem. 258, 11599-11609 (1983) MEDLINE 84008157 REFERENCE 63 (bases 62050 to 62050; 62279 to 62279; 62283 to 62283) AUTHORS Treisman,R., Orkin,S.H. and Maniatis,T. TITLE Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes JOURNAL Nature 302, 591-596 (1983) MEDLINE 83167534 REFERENCE 64 (bases 62190 to 62244) AUTHORS Chang,J.C., Alberti,A. and Kan,Y.W. TITLE A beta-thalassemia lesion abolishes the same MstII site as the sickle mutation JOURNAL Nucleic Acids Res. 11, 7789-7794 (1983) MEDLINE 84069804 REFERENCE 65 (bases 50716 to 53976) AUTHORS Maeda,N., Bliska,J.B. and Smithies,O. TITLE Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene JOURNAL Proc. Natl. Acad. Sci. U.S.A. 80, 5012-5016 (1983) MEDLINE 83273742 REFERENCE 66 (sites) AUTHORS Kimura,A., Ohta,Y., Fukumaki,Y. and Takagi,Y. TITLE A fusion gene in man: DNA sequence analysis of the abnormal globin gene of hemoglobin Miyada JOURNAL Biochem. Biophys. Res. Commun. 119, 968-974 (1984) MEDLINE 84178511 REFERENCE 67 (sites) AUTHORS Kazazian,H.H.Jr.., Orkin,S.H., Antonarakis,S.E., Sexton,J.P., Boehm,C.D. and Waber,P.G. TITLE Molecular characterization of seven beta-thalassemia mutations in Asian Indians JOURNAL EMBO J. 3, 593-596 (1984) MEDLINE 84182531 REFERENCE 68 (sites) AUTHORS Guida,S., Giglioni,B., Ottolenghi,S., Camaschella,C. and Saglio,G. TITLE The beta-globin gene in Sardinian delta-beta-0-thalassemia carries a C -> T nonsense mutation at codon 39 JOURNAL EMBO J. 3, 785-787 (1984) MEDLINE 84207935 REFERENCE 69 (sites) AUTHORS Giglioni,B., Casini,C., Mantovani,R.M., Merli,S., Comi,P., Ottolenghi,S., Saglio,G., Camaschella,C. and Mazza,U. TITLE A molecular study of a family with Greek hereditary persistence of fetal hemoglobin and beta-thalassemia JOURNAL EMBO J. 3, 2641-2645 (1984) MEDLINE 85076587 REFERENCE 70 (bases 61557 to 61623) AUTHORS Semenza,G.L., Malladi,P., Surrey,S., Delgrosso,K., Poncz,M. and Schwartz,E. TITLE Detection of a novel DNA polymorphism in the beta-globin gene cluster JOURNAL J. Biol. Chem. 259, 6045-6048 (1984) MEDLINE 84212404 REFERENCE 71 (sites) AUTHORS Orkin,S.H., Antonarakis,S.E. and Kazazian,H.H.Jr.. TITLE Base substitution at position -88 in a beta-thalassemic globin gene JOURNAL J. Biol. Chem. 259, 8679-8681 (1984) MEDLINE 84264471 REFERENCE 72 (bases 45336 to 47463) AUTHORS Chang,L.Y. and Slightom,J.L. TITLE Isolation and nucleotide sequence analysis of the beta-type globin pseudogene from human, gorilla and chimpanzee JOURNAL J. Mol. Biol. 180, 767-784 (1984) MEDLINE 85134894 REFERENCE 73 (sites) AUTHORS Grindlay,G.J., Lanyon,W.G., Allan,M. and Paul,J. TITLE Alternative sites of transcription initiation upstream of the canonical cap site in human gamma-globin and beta-globin genes JOURNAL Nucleic Acids Res. 12, 1811-1821 (1984) MEDLINE 84144070 REFERENCE 74 (sites) AUTHORS Stoeckert,C.J., Collins,F.S. and Weissman,S.M. TITLE Human fetal globin DNA sequences suggest novel conversion event JOURNAL Nucleic Acids Res. 12, 4469-4479 (1984) MEDLINE 84247314 REFERENCE 75 (sites) AUTHORS Mager,D.L. and Henthorn,P.S. TITLE Identification of a retrovirus-like repetitive element in human DNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 81, 7510-7514 (1984) MEDLINE 85063820 REFERENCE 76 (bases 19120 to 61776) AUTHORS Collins,F.S. and Weissman,S.M. TITLE The molecular genetics of human hemoglobin JOURNAL Prog. Nucleic Acid Res. Mol. Biol. 31, 315-462 (1984) MEDLINE 85167133 REFERENCE 77 (bases 34276 to 34276; 34282 to 34282; 34321 to 34321) AUTHORS Gilman,J.G. and Huisman,T.H. TITLE DNA sequence variation associated with elevated fetal gamma-G globin production JOURNAL Blood 66, 783-787 (1985) MEDLINE 86000973 REFERENCE 78 (sites) AUTHORS Ruskin,B., Greene,J.M. and Green,M.R. TITLE Cryptic branch point activation allows accurate in vitro splicing of human beta-globin intron mutants JOURNAL Cell 41, 833-844 (1985) MEDLINE 85228234 REFERENCE 79 (sites) AUTHORS Lang,K.M. and Spritz,R.A. TITLE Cloning specific complete polyadenylated 3'-terminal cDNA segments JOURNAL Gene 33, 191-196 (1985) MEDLINE 85205333 REFERENCE 80 (bases 1 to 16593) AUTHORS Li,Q., Powers,P.A. and Smithies,O. TITLE Nucleotide sequence of 16 kilobase pairs of DNA 5' to the human epsilon-globin gene JOURNAL J. Biol. Chem. 260, 14901-14910 (1985) MEDLINE 86059328 REFERENCE 81 (sites) AUTHORS Gelinas,R., Endlich,B., Pfeiffer,C., Yagi,M. and Stamatoyannopoulos,G. TITLE G to A substitution in the distal CCAAT box of the alpha-gamma-globin gene in Greek hereditary persistence of fetal haemoglobin JOURNAL Nature 313, 323-325 (1985) MEDLINE 85111130 REFERENCE 82 (sites) AUTHORS Collins,F.S., Metherall,J.E., Yamakawa,M., Pan,J., Weissman,S.M. and Forget,B.G. TITLE A point mutation in the alpha-gamma-globin gene promoter in Greek hereditary persistence of fetal haemoglobin JOURNAL Nature 313, 325-326 (1985) MEDLINE 85111131 REFERENCE 83 (bases 67071 to 73308) AUTHORS Hattori,M., Hidaka,S. and Sakaki,Y. TITLE Sequence analysis of a KpnI family member near the 3'end of human beta-globin gene JOURNAL Nucleic Acids Res. 13, 7813-7827 (1985) MEDLINE 86067199 REFERENCE 84 (sites) AUTHORS van Santen,V.L. and Spritz,R.A. TITLE mRNA precursor splicing in vivo: Sequence requirements determined by deletion analysis of an intervening sequence JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 2885-2889 (1985) MEDLINE 85190601 REFERENCE 85 (sites) AUTHORS Tuan,D., Solomon,W., Li,Q. and London,I.M. TITLE The 'beta-like-globin' gene domain in human erythroid cells JOURNAL Proc. Natl. Acad. Sci. U.S.A. 82, 6384-6388 (1985) MEDLINE 86016706 REFERENCE 86 (sites) AUTHORS Chabot,B., Black,D.L., LeMaster,D.M. and Steitz,J.A. TITLE The 3' splice site of pre-messenger RNA is recognized by a small nuclear ribonucleoprotein JOURNAL Science 230, 1344-1349 (1985) MEDLINE 86070214 REFERENCE 87 (bases 21354 to 21360) AUTHORS Collins,F.S. JOURNAL Unpublished (1986) REFERENCE 88 (bases 58799 to 58958; 63036 to 63295) AUTHORS Popovich,B.W., Rosenblatt,D.S., Kendall,A.G. and Nishioka,Y. TITLE Molecular characterization of an atypical beta-thalassemia caused by a large deletion in the 5' beta-globin gene region JOURNAL Am. J. Hum. Genet. 39, 797-810 (1986) MEDLINE 87097229 REFERENCE 89 (bases 54874 to 54892) AUTHORS Lapoumeroulie,C., Pagnier,J., Bank,A., Labie,D. and Krishnmoorthy,R. TITLE Beta thalassemia due to a novel mutation in IVS 1 sequence donor site consensus sequence creating a restriction site JOURNAL Biochem. Biophys. Res. Commun. 139, 709-713 (1986) MEDLINE 87025783 REFERENCE 90 (bases 62373 to 62419) AUTHORS Metherall,J.E., Collins,F.S., Pan,J., Weissman,S.M. and Forget,B.G. TITLE Beta-0 thalassemia caused by a base substitution that creates an alternative splice acceptor site in an intron JOURNAL EMBO J. 5, 2551-2557 (1986) MEDLINE 87053821 REFERENCE 91 (bases 37640 to 37677; 40162 to 40199) AUTHORS Tate,V.E., Hill,A.V., Bowden,D.K., Sadler,J.R., Weatherall,D.J. and Clegg,J.B. TITLE A silent deletion in the beta-globin gene cluster JOURNAL Nucleic Acids Res. 14, 4743-4750 (1986) MEDLINE 86259055 REFERENCE 92 (sites) AUTHORS Prchal,J.T., Cashman,D.P. and Kan,Y.W. TITLE Hemoglobin Long Island is caused by a single mutation (adenine to cytosine) resulting in a failure to cleave amino-terminal methionine JOURNAL Proc. Natl. Acad. Sci. U.S.A. 83, 24-27 (1986) MEDLINE 86094343 REFERENCE 93 (bases 59589 to 59718; 72211 to 72340) AUTHORS Gilman,J.G. and Abraham,J. TITLE DNA sequence analysis of the Dutch beta-0-thalassemia deletion JOURNAL Biomed. Biochim. Acta 46, 131-135 (1987) REFERENCE 94 (bases 43723 to 50721) AUTHORS Miyamoto,M.M., Slightom,J.L. and Goodman,M. TITLE Phylogenetic relations of humans and African apes from DNA sequences in the pseudo-eta-globin region JOURNAL Science 238, 369-373 (1987) MEDLINE 88018021 REFERENCE 95 (sites) AUTHORS Fei,Y.J., Stoming,T.A., Efremov,G.D., Efremov,D.G., Battacharia,R., Gonzalez-Redondo,J.M., Altay,C., Gurgey,A. and Huisman,T.H. TITLE Beta-thalassemia due to a T->A mutation within the ATA box JOURNAL Biochem. Biophys. Res. Commun. 153, 741-747 (1988) MEDLINE 88251410 REFERENCE 96 (bases 55038 to 55052) AUTHORS Atweh,G.F., Brickner,H.E., Zhu,X.-X., Kazazian,H.H.Jr.. and Forget,B.G. TITLE New amber mutation in a beta-thalassemic gene with nonmeasurable levels of mutant messenger RNA in vivo JOURNAL J. Clin. Invest. 82, 557-561 (1988) MEDLINE 88299168 REFERENCE 97 (sites) AUTHORS Engelke,D.R., Hoener,P.A. and Collins,F.S. TITLE Direct sequencing of enzymatically amplified human genomic DNA JOURNAL Proc. Natl. Acad. Sci. U.S.A. 85, 544-548 (1988) MEDLINE 88124877 REFERENCE 98 (sites) AUTHORS Guidal,C., Lapoumeroulie,C., Krishnamoorthy,R. and Elion,J. TITLE Sequence correction and reassignment of the TaqI polymorphic site in the human inter-gamma-globin gene region, an African-specific marker JOURNAL Unpublished (1993) REFERENCE 99 (bases 16594 to 19305) AUTHORS Trepicchio,W.L., Dyer,M.A., Hardison,R.G. and Baron,M.H. TITLE Upstream regulatory region of the human embryonic beta-like globin gene, epsilon JOURNAL Unpublished (1993) COMMENT On Feb 16, 1994 this sequence version replaced gi:183807. [1] cRNA fragments. [2] mRNA. [5] sites; polyadenylation signal and site for the beta gene. [4] cDNA from normal and thalassemic mRNAs. [6] cDNA. [9] mRNA and cDNA fragments. [10] mRNA. [7] cDNA. [13] see comment below for 35854 to 35946 - may be 40770 to 40862. [19] sites; amber mutation at codon 17 of the beta chain. [22] sites; gene order for the beta-like globin cluster. [27] sites; consensus sequences in the promoter regions. [40] sites; mutation associated with Hb Vicksburg. [41] beta thalassemia DNA. [42] sites; mutation associated with beta-0 thalassemia. [35] sites; mutation associated with beta-plus thalassemia. [36] sites; mutation associated with beta-0 thalassemia. [37] six alleles over this span. [32] sites; mutations associated with beta-0 thalassemia. [34] sites; mutation associated with beta-0 thalassemia. [52] sites; alternative cap sites for mRNA. [53] sites; mutation associated with beta-plus thalassemia. [56] sites; deletion mutation associated with beta-0 thalassemia. [48] sites; mutations associated with beta thalassemias. [49] sites; deletion mutation; for sequence, see separate entry. [62] DNA from Kurdish Jew with thalassemia. [58] sites; promoter region for beta gene. [59] sites; termini for RNA polymerase III transcripts. [60] sites; alternative cap sites for mRNA. [61] sites; deletion mutations associated with thalassemias;. [65] for the R allele;. [73] sites; beta and gamma gene cap sites. [71] sites; mutation associated with beta thalassemia. [66] sites; Miyada Hb lesion; for sequence, see separate entry. [75] sites; hsRTVL-H element; for sequence, see separate entry. [67] sites; mutations associated with thalassemia. [68] sites; mutation associated with thalassemia. [69] sites; mutation associated with thalassemia. [76] see comment; review. [74] sites; mutations in the A-gamma gene. [81] sites; mutation in promoter region leading to HPFH;. [82] sites; mutation in promoter region leading to HPFH. [85] sites; DNAse I hypersensitivity sites in the region. [78] sites; cryptic branch points in beta IVS1. [79] sites; 3' segments of beta and G-gamma cDNAs. [84] sites; mutational analysis of G-gamma IVS-2. [86] sites; small nuclear ribonucleoprotein binding site to mRNA. [92] sites; hemoglobin Long Island mutation. [94] revises [72]. [95] sites; mutations resulting in beta-thalassemia. [97] sites; sickle cell anemia mutation site. [30] sites; thalassemia mutations. [43] sites; thalassemia mutations. [44] sites; thalassemia mutation. [21] sites; thalassemia mutation. [90] beta-0 thalassemia mutations. This 73 kb sequence, which includes all of the known beta genes in the cluster on chromosome 11, was compiled from the following sources primarily: bases references ------ ------------ 1 to 10409 [80] 10410 to 13774 [55] 13775 to 16594 [80] 16595 to 19304 [99] 19305 to 21381 [23], [28], [39] 21382 to 32352 [63; see acknowledgments therein; bases 31888-32020 sequenced on one strand only] 32353 to 43728 [29] 43729 to 50715 [94] 50716 to 67204 [47], [62] 67205 to 73308 [83] Other sequence work is referenced and annotated below. Oliver Smithies provided the sequence in [80] via Arpanet and Francis Collins supplied a diskette with the sequence in [76]. Computer-readable sequence for [94] kindly provided by M.M.Miyamoto, 15-FEB-1988. The five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon -G-gamma -A-gamma -delta -beta-3' [22] Additionally, the pseudogene beta-1 is located between the A-gamma and delta genes [72]. A region 5' to the epsilon gene was thought to be another pseudogene; however [55] shows this not to be so. These embryonic, fetal and adult beta-like genes have the same overall exonic structure, leading to the conclusion that they are derived from one ancestral gene. In particular, they have many consensus sequences and repetitive sequences in common which have been analyzed by [27] and [76]. Epsilon gene ------------ The epsilon globin gene (hbe below) is normally expressed in the embryonic yolk sac: two epsilon chains together with two zeta chains (an alpha-like globin; see separate entry) constitute the embryonic hemoglobin Hb Gower I; two epsilon chains together with two alpha chains form the embryonic Hb Gower II. Both of these embryonic hemoglobins are normally supplanted by fetal, and later, adult hemoglobin. The promoter region sequences 'ccaat', 'ata' and 'cttccg' found at 19403, 19458 and 19495 are characteristic of all human beta-like genes, as well as of some other mammalian genes, and are thought to influence initiation of transcription and translation [27],[76]. However, at least nine alternative cap sites which do not possess these conserved sequences have been found upstream from the so-called canonical cap sites at 19486 and 19488 [52],[60]. The Alu family sequences found at 16892-17158 and 17927-18190 are typical of the 5' flanking regions of the beta-like globin genes [23],[39]. The first of these bipolar repeats has been shown to be active as a template for RNA polymerase III [39]. G-gamma and A-gamma genes ------------------------- The gamma globin genes (hbgg and hbga below) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions (HPFH or 'hereditary persistence of fetal hemoglobin'), gamma chain production continues into adulthood. The mapping of deletions in these pathologies is therefore of special interest with regard to developmental control mechanisms. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product and alanine is found in the A-gamma product. The former is predominant at birth. Because of the sequence identity of the two genes over large stretches, it was not always possible in the early work to know which sequence was being investigated [13],[15],[17]. Moreover, because allelic variation has been reported for each of these non-allelic genes, further sequence work is required to determine the consensus sequence for each. Thus far the sequences of two A-gamma alleles have been reported ([24]; see separate entry which annotates the allelic variation). The second introns for the hbgg and hbga genes shown below contain 886 and 866 bases respectively, while their alleles on the opposing chromosome have 904 and 876 bases for the corresponding introns. [24] and [29] present an analysis of this phenomenon and conclude that intergenic exchange can occur in human germ line cells with significant frequency. Given the above-mentioned uncertainties with regard to polymorphism and material, differences, where annotated, are treated as variations rather than as conflicts. The promoter region sequences 'ccaat', 'ata' and 'cttctg' found at bases 34390, 34448 and 34485 in the hbgg gene, and bases 39326, 39384 and 39421 in the hbga gene, are characteristic of all beta-like genes, as well as of some other mammalian genes, and are thought to influence transcription and translation [27],[76]. The gamma genes each manifest duplicate 'ccaat' boxes at positions 34363 (hbgg) and 39299 (hbga). Alternative cap sites are active in vitro upstream from the canonical cap sites at 34478 and 39414: at bases 34398, 34408, 34418 and 34428 for hbgg, and at bases 39334, 39344, 39354 and 39364 for hbga [73]. Alternative cap sites have also been reported for epsilon and beta mRNAs when there is no duplication of the 'ccaat' sequence. [81] and [82] show that the distal 'ccaat' box for the hbga gene (for the B allele -- see separate sequence) has some vital function: a g -> a mutation at base 39297 is apparently responsible for one form of Greek HPFH. The Alu family sequences found at bases 32390-32723 (approx.) and 37325-37562 (approx.) are typical of the beta-like globin Alu's [27],[76],[31],[29]. A study of the hbgg repeat has revealed RNA transcription by polymerase III [31]( also reported for Alu regions in the 5' flanks of the epsilon and beta genes). Pseudo-beta-1 ------------- Human, gorilla and chimpanzee beta-like pseudogenes were sequenced and compared (see separate entries for the other primate sequences) by [72] and revised by [94]. The pseudogene structure was deduced through comparison with the A-gamma globin gene. Base substitutions in the initiation codon and in codons downstream, that create internal termination signals in exons 2 and 3, make this sequence a pseudogene. Delta and beta genes -------------------- The delta and beta genes (denoted hbd and hbb below) are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. The sequence given below has been reconstructed from the sequences reported by [47] and [62]: the mutation at base 62143 is apparently sufficient to distinguish the Kurdish Jew thalassemic sequence from a normal (consensus) beta globin DNA; [62] has resolved all sequence differences to date with exception of the differences reported herein as variations. The promoter region sequences 'ccaat', 'ata' and 'cttctg' found at bases 54672, 54709 and 54747 in the delta gene, and at bases 62061, 62106 and 62144 in the beta gene, are characteristic of all beta-like genes, as well as of some other mammalian genes, and are thought to influence transcription and translation [27],[76]. However, alternative cap sites have been found for these genes as well as other beta-like genes [58],[73]. [95] describes the mutation (substitution of 'a' for 't' at position 62107, thereby destroying the promoter) found in an Hb Lepore-beta+ -thalassemia patient, who was homozygous for this mutation. The father who had the simple beta-thalassemia trait was found to be heterozygous. A form of thalassemia exists, where 19 bp are added after the first exon, starting at position 62390 and ending at a stop codon at position 62406-62408 [30],[43],[57]. This aberrant splicing is caused by a mutation of 'g' to 'a' in the first intron of beta-hemoglobin at position 62388. The substitution of a 'g' for a 't' at position 62394 also causes premature splicing and results in an abnormal and abbreviated beta hemoglobin [90]. Another form of beta-thalassemia is produced by the substitution of an 'a' for a 'g' at position 62632. This causes a readthrough at the exon/intron boundary of exon 2/intron 2 [44]. The Alu family sequences found at bases 50915, 51976, 65513 and 66776 are again typical of the beta-like globin Alu's. These sequences are of considerable interest in relation to regulation, recombination and transcription by RNA polymerase III. There are non-Alu repetitive elements in the gene cluster that have been partially characterized: the EC-1 repeat [38] and a retrovirus-like element in the 3' flank about 300 kb downstream of this sequence [75] (see separate entry); there are numerous repeats in the 5' flank which will be included in a future update [80]. Reference [83] has characterized a novel KpnI family sequence in the 3' flank of the cluster. Potential polyadenylation signals were identified for the following genes: hbe positions 21055-21060 hbgg positions 36043-36048 hbga positions 40959-40964 hbd positions 56365-56370 hbb positions 63718-63723. FEATURES Location/Qualifiers source 1..73308 /organism="Homo sapiens" /db_xref="taxon:9606" /map="11p15.5" repeat_region 10597..10611 /note="Alu flank repeat 5' copy" repeat_region 10612..10924 /note="Alu family repeat" repeat_region 10925..10939 /note="Alu flank repeat 3' copy" repeat_unit complement(16918..17218) /rpt_family="Alu" repeat_unit 17940..18231 /rpt_family="Alu" precursor_RNA 19289..21080 /note="hbe mRNA (alt.) [23],[52],[60]" precursor_RNA 19486..21080 /note="hbe mRNA (alt.) [23],[52],[60]" precursor_RNA 19488..21080 /note="hbe mRNA (alt.) [23],[52],[60]" gene 19541..19632 /gene="HBE1" CDS join(19541..19632,19755..19977,20833..20961) /note="epsilon-globin" /codon_start=1 /protein_id="AAA16330.1" /db_xref="PID:g455993" /db_xref="GI:455993" /translation="MVHFTAEEKAAVTSLWSKMNVEEAGGEALGRLLVVYPWTQRFFD SFGNLSSPSAILGNPKVKAHGKKVLTSFGDAIKNMDNLKPAFAKLSELHCDKLHVDPE NFKLLGNVMVIILATHFGKEFTPEVQAAWQKLVSAVAIALAHKYH" exon <19541..19632 /gene="HBE1" /note="epsilon-globin" /number=1 intron 19633..19754 /note="hbe intron 1 [23]" exon 19755..19977 /number=2 intron 19978..20832 /note="hbe intron 2 [23]" exon 20833..>20961 /note="epsilon-globin" /number=3 variation 20983 /note="g in [76]; c in [23]" old_sequence replace(21372..21378,"") /citation=[76] unsure 31888..32020 /note="sequenced on one strand only [76]" repeat_region 32390..32406 /note="Alu flank repeat 5' copy [31]" repeat_region 32407..32711 /note="Alu family repeat [31]" variation 32608 /note="g in [29]; a in [31]" repeat_region 32712..32728 /note="Alu flank repeat 3' copy [31]" variation 32743..32744 /note="ag in [29]; ga in [31]" variation 33186 /note="a in [29]; g in [31]" variation 33198 /note="a in [29]; g in [31]" mutation 34276 /note="c in wt; g in persons with elevated gamma chain [77]" mutation 34282 /note="c in wt; t in persons with elevated gamma chain [77]" mutation 34321 /note="c in wt; t in high G-gamma SS; beta thalassemia; and in low Hb F G-gamma-beta+-HPHF and HPFH [77]" mutation 34361 /note="g in wt; a in persons with elevated gamma chain [77]" precursor_RNA 34478..36069 /note="hbgg mRNA [15],[24],[27]" gene 34531..34622 /gene="HBG2" exon <34531..34622 /gene="HBG2" /note="G-gamma globin" /number=1 CDS join(34531..34622,34745..34967,35854..35982) /note="G-gamma globin" /codon_start=1 /protein_id="AAA16331.1" /db_xref="PID:g455994" /db_xref="GI:455994" /translation="MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD SFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPE NFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTGVASALSSRYH" intron 34623..34744 /note="hbgg intron 1 [24]" exon 34745..34967 /number=2 intron 34968..35853 /note="hbgg intron 2 [24]" exon 35854..>35982 /note="G-gamma globin" /number=3 conflict replace(37504,"t") /citation=[98] /citation=[29] mutation 37657..40179 /note="g-25 kb-c in wt; gc in silent deletion [91]" variation replace(37993,"t") /note="t in all Benin-type sickle cell (beta-S) chromosomes and some African beta-A chromosomes; t abolishes a TaqI site" /citation=[98] /citation=[29] mutation 39297 /note="g in wt (b allele, see separate sequence); a in HPFH [81],[82]" precursor_RNA 39414..40985 /note="hbga mRNA [5],[15],[24],[27]" variation 39438 /note="a in [29]; g in [15]" exon <39467..39558 /gene="HBG1" /note="A-gamma globin" /number=1 gene 39467..39558 /gene="HBG1" CDS join(39467..39558,39681..39903,40770..40898) /note="A-gamma globin" /codon_start=1 /protein_id="AAA16332.1" /db_xref="PID:g455995" /db_xref="GI:455995" /translation="MGHFTEEDKATITSLWGKVNVEDAGGETLGRLLVVYPWTQRFFD SFGNLSSASAIMGNPKVKAHGKKVLTSLGDAIKHLDDLKGTFAQLSELHCDKLHVDPE NFKLLGNVLVTVLAIHFGKEFTPEVQASWQKMVTAVASALSSRYH" intron 39559..39680 /note="hbga intron 1 [24]" exon 39681..39903 /number=2 intron 39904..40769 /note="hbga intron 2 [17],[24]" exon 40770..>40898 /note="A-gamma globin" /number=3 variation 43782..43784 /note="gat in [94]; gt in [76]" variation 43830..43832 /note="ttg in [94]; tg in [76]" variation 43843 /note="t in [94]; c in [76]" variation 44122 /note="t in [94]; c in [76]" variation 45069..45077 /note="aaaaaaaaa in [94]; aa in [76]" variation 45227..45228 /note="ca in [94]; ctca in [76]" variation 45280 /note="t in [94]; c in [76]" variation 45297 /note="c in [94]; t in [76]" variation 45299 /note="t in [94]; c in [76]" variation 45309..45311 /note="cat in [94]; ct in [76]" variation 45317..45319 /note="tta in [94]; ta in [76]" variation 45321..45323 /note="tag in [94]; tg in [76]" mRNA 45657..47370 /note="pseudo-hbp mRNA [72]" CDS join(45710..45800,45922..46145,46997..47124) /note="pseudo-hbp" /pseudo /codon_start=1 exon <45710..45800 /note="pseudo-hbp, [72]" /number=1 intron 45801..45923 /note="pseudo-hbp intron 1 (no splice consensus at 45941 [17],[24],[72]; putative" exon 45922..46145 /note="pseudo-hbp, [72]" /pseudo /number=2 intron 46146..46996 /note="pseudo-hbp intron 2 (no splice consensus at 46164 [72]; putative" exon 46997..>47124 /note="pseudo-hbp, [72]" /number=3 repeat_region complement(50889..50894) /note="Alu flank repeat 3' copy [47],[62]" repeat_region complement(50915..51198) /note="Alu family repeat [47],[62]" repeat_region complement(51199..51204) /note="Alu flank repeat 5' copy [47],[62]" repeat_region 51966..51975 /note="Alu flank repeat 5' copy [62]" repeat_region 51976..52259 /note="Alu family repeat [31],[62]" repeat_region 52286..52295 /note="Alu flank repeat 3' copy [62]" precursor_RNA 54740..56389 /note="hbd mRNA [25]" gene 54790..54881 /gene="HBD" CDS join(54790..54881,55010..55232,56131..56259) /note="delta-globin" /codon_start=1 /protein_id="AAA16333.1" /db_xref="PID:g455996" /db_xref="GI:455996" /translation="MVHLTPEEKTAVNALWGKVNVDAVGGEALGRLLVVYPWTQRFFE SFGDLSSPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFSQLSELHCDKLHVDPE NFRLLGNVLVCVLARNFGKEFTPQMQAAYQKVVAGVANALAHKYH" exon <54790..54881 /gene="HBD" /note="delta-globin" /number=1 intron 54882..55009 /note="hbd intron 1 [25]" mutation 54886 /note="g in wt; a in beta thalassemia [89]" exon 55010..55232 /number=2 mutation 55047 /note="g in wt; t in beta-thalassemia Glu->stop" intron 55233..56130 /note="hbd intron 2 [25]" variation 55523 /note="ct in [54],[62],[76]; tc in [25]" variation 55571..55572 /note="ct in [62],[76]; c in [25]; cc in [54]" exon 56131..>56259 /note="delta-globin" /number=3 mutation 58855..63093 /note="a-4239 bp-c in wt; ac in atypical beta-thalassemia [88]" mutation 59663..72286 /note="t-12622 bp-t in wt; tt in Dutch beta-0- thalassemia [93]" variation 60745..60750 /note="tatttt in [62],[76]; t in [37]" variation 60832 /note="a in [37],[62],[76]; g in [51]" variation 60842 /note="c in [62],[76]; ca in [37],[51]" variation 61148 /note="c in [51],[62],[76]; g in [51]" variation 61294 /note="c in [62],[76]; t in [51]" variation 61308 /note="t in [62],[76]; tt in [51]" allele 61586 /note="t in wt; c in Albanian allele (produces RsaI site) [70]" allele 61608..61609 /note="tt in wt; tatat in Albanian allele [70]" variation 61663 /note="a in [62],[76]; g in [51]" variation 61753 /note="gc in [62],[76]; g in [51]" variation 61773 /note="g in [62]; a in [76]" variation 61797 /note="t in [54],[62],[76]; c in [51]" variation 61824 /note="g in [62],[76]; c in [51]" variation 61922 /note="g in [51],[62],[76]; c in [41]" variation 61932 /note="a in [51],[62],[76]; t in [41]" mutation 62050 /note="c in wt; g in beta-thalassemia [63]" mutation 62107 /note="t in normal promoter; a in thalassemia patient (Hb Lepore-beta+ -thal)" mutation 62109 /note="a in [26],[41],[51]; c in [62],[76],[J. Biol. C" precursor_RNA 62137..63742 /note="hbb mRNA [5],[11],[10],[7],[26]" variation 62156 /note="c in [62],[76]; t in [48]" gene 62187..62278 /gene="HBB" CDS join(62187..62278,62390..62408) /note="beta-globin thalassemia" /codon_start=1 /protein_id="AAA16335.1" /db_xref="PID:g455998" /db_xref="GI:455998" /translation="MVHLTPEEKSAVTALWGKVNVDEVGGEALGSLFSHP" CDS join(62187..62278,62409..62631,63482..63610) /note="beta-globin" /codon_start=1 /protein_id="AAA16334.1" /db_xref="PID:g455997" /db_xref="GI:455997" /translation="MVHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFE SFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPE NFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH" exon <62187..62278 /gene="HBB" /note="beta-globin thalassemia, [30],[43]" /number=1 exon <62187..62278 /gene="HBB" /note="beta-globin" /number=1 variation 62195 /gene="HBB" /note="c in [26],[62],[76]; t in [48]" mutation 62205..62207 /gene="HBB" /note="gag in wt; gg in beta-thalassemia [64]" mutation 62206 /gene="HBB" /note="a in normal hbb; t in sickle cell anemia 78]" mutation 62238 /gene="HBB" /note="a in wt; t in thalassemia [Ann. N.Y. Acad. Sci. 344, 113-119 (1980)]" intron 62279..62389 /gene="HBB thalassemia" mutation 62279 /gene="HBB thalassemia" /note="g in wt; a in thalassemia [63]" intron 62279..62408 /note="hbb intron 1 [10],[26],[54]" gene 62279..62389 /gene="HBB thalassemia" mutation 62283 /gene="HBB thalassemia" /note="g in wt; c in thalassemia [63]" mutation 62284 /gene="HBB thalassemia" /note="t in wt; c in thalassemia [63]" mutation 62388 /gene="HBB thalassemia" /note="g in wt; a in thalassemia [30],[43],[57],[90]" exon 62390..>62408 /note="beta-globin thalassemia, [30],[43]" /number=2 mutation 62394 /note="t in wt; g in thalassemia [90]" exon 62409..62631 /number=2 mutation 62430 /note="g in wt; a in a form of thalassemia [30]" mutation 62632 /note="g in wt; a in a form of thalassemia [44]" intron 62632..63481 /note="hbb intron 2 [10],[12],[26]" variation 62647 /note="c in [26],[48],[62],[76]; g in [48]" variation 62705 /note="g in [26],[62],[76]; t in [48]" variation 62712 /note="c in [26],[62],[76]; t in [48]" variation 63297 /note="t in [26],[48],[62],[76]; c in [48]" mutation 63376 /note="c in wt; g thalassemia [63] (causes an extra exon)" exon 63482..>63610 /note="beta-globin" /number=3 variation 63830..63831 /note="ta in [62],[76]; t in [26]" variation 63918 /note="c in [62],[76]; cc in [26]" mutation 63918..63919 /note="ct in wt; cct in a form of thalassemia [45]" variation 63957..63958 /note="aa in [37],[62],[76]; tt in [26]" mutation 63957..63958 /note="tt in wt; aa in a form of thalassemia [45]" variation 63974 /note="g in [37],[62],[76]; c in [26]" repeat_region 65490..65502 /note="Alu flank repeat 5' copy [62],[76]" repeat_region 65513..65767 /note="Alu family repeat [62],[76]" repeat_region 65768..65780 /note="Alu flank repeat 3' copy [62],[76]" repeat_region 66765..66775 /note="Alu flank repeat 5' copy [62],[76]" repeat_region 66776..67042 /note="Alu family repeat [62],[76]" repeat_region 67069..67079 /note="Alu flank repeat 3' copy [62],[76]" repeat_region 67071..73195 /note="KpnI family repeat [83]" BASE COUNT 22068 a 14146 c 14785 g 22309 t ORIGIN 1 bp upstream of EcoRI site; chromosome 11p15 [J. Biol. Chem. 260]. 1 gaattctaat ctccctctca accctacagt cacccatttg gtatattaaa gatgtgttgt 61 ctactgtcta gtatccctca agtagtgtca ggaattagtc atttaaatag tctgcaagcc 121 aggagtggtg gctcatgtct gtaattccag cactggagag gtagaagtgg gaggactgct 181 tgagctcaag agtttgatat tatcctggac aacatagcaa gacctcgtct ctacttaaaa 241 aaaaaaaaat tagccaggca tgtgatgtac acctgtagtc ccagctactc aggaggccga 301 aatgggagga tcccttgagc tcaggaggtc aaggctgcag tgagacatga tcttgccact 361 gcactccagc ctggacagca gagtgaaacc ttgcctcacg aaacagaata caaaaacaaa 421 caaacaaaaa actgctccgc aatgcgcttc cttgatgctc taccacatag gtctgggtac 481 tttgtacaca ttatctcatt gctgttcgta attgttagat taattttgta atattgatat 541 tattcctaga aagctgaggc ctcaagatga taacttttat tttctggact tgtaatagct 601 ttctcttgta ttcaccatgt tgtaactttc ttagagtagt aacaatataa agttattgtg 661 agtttttgca aacacagcaa acacaacgac ccatatagac attgatgtga aattgtctat 721 tgtcaattta tgggaaaaca agtatgtact ttttctacta agccattgaa acaggaataa 781 cagaacaaga ttgaaagaat acattttccg aaattacttg agtattatac aaagacaagc 841 acgtggacct gggaggaggg ttattgtcca tgactggtgt gtggagacaa atgcaggttt 901 ataatagatg ggatggcatc tagcgcaatg actttgccat cacttttaga gagctcttgg 961 ggaccccagt acacaagagg ggacgcaggg tatatgtaga catctcattc tttttcttag 1021 tgtgagaata agaatagcca tgacctgagt ttatagacaa tgagcccttt tctctctccc 1081 actcagcagc tatgagatgg cttgccctgc ctctctacta ggctgactca ctccaaggcc 1141 cagcaatggg cagggctctg tcagggcttt gatagcacta tctgcagagc cagggccgag 1201 aaggggtgga ctccagagac tctccctccc attcccgagc agggtttgct tatttatgca 1261 tttaaatgat atatttattt taaaagaaat aacaggagac tgcccagccc tggctgtgac 1321 atggaaacta tgtagaatat tttgggttcc attttttttt ccttctttca gttagaggaa 1381 aaggggctca ctgcacatac actagacaga aagtcaggag ctttgaatcc aagcctgatc 1441 atttccatgt catactgaga aagtccccac ccttctctga gcctcagttt ctctttttat 1501 aagtaggagt ctggagtaaa tgatttccaa tggctctcat ttcaatacaa aatttccgtt 1561 tattaaatgc atgagcttct gttactccaa gactgagaag gaaattgaac ctgagactca 1621 ttgactggca agatgtcccc agaggctctc attcagcaat aaaattctca ccttcaccca 1681 ggcccactga gtgtcagatt tgcatgcact agttcacgtg tgtaaaaagg aggatgcttc 1741 tttcctttgt attctcacat acctttagga aagaacttag cacccttccc acacagccat 1801 cccaataact catttcagtg actcaaccct tgactttata aaagtcttgg gcagtataga 1861 gcagagatta agagtacaga tgctggagcc agaccacctg agtgattagt gactcagttt 1921 ctcttagtaa ttgtatgact cagtttcttc atctgtaaaa tggagggttt tttaattagt 1981 ttgtttttga gaaagggtct cactctgtca cccaaatggg agtgtagtgg caaaatctcg 2041 gctcactgca acttgcactt cccaggctca agcggtcctc ccacctcaac atcctgagta 2101 gctggaacca caggtacaca ccaccatacc tcgctaattt tttgtatttt tggtagagat 2161 ggggtttcac atgttacaca ggatggtctc agactccgga gctcaagcaa tctgcccacc 2221 tcagccttcc aaagtgctgg gattataagc atgattacag gagttttaac aggctcataa 2281 gattgttctg cagcccgagt gagttaatac atgcaaagag tttaaagcag tgacttataa 2341 atgctaacta ctctagaaat gtttgctagt attttttgtt taactgcaat cattcttgct 2401 gcaggtgaaa actagtgttc tgtactttat gcccattcat ctttaactgt aataataaaa 2461 ataactgaca tttattgaag gctatcagag actgtaatta gtgctttgca taattaatca 2521 tatttaatac tcttggattc tttcaggtag atactattat tatccccatt ttactacagt 2581 taaaaaaact acctctcaac ttgctcaagc atacactctc acacacacaa acataaacta 2641 ctagcaaata gtagaattga gatttggtcc taattatgtc tttgctcact atccaataaa 2701 tatttattga catgtacttc ttggcagtct gtatgctgga tgctggggat acaaagatgt 2761 ttaaatttaa gctccagtct ctgcttccaa aggcctccca ggccaagtta tccattcaga 2821 aagcattttt tactctttgc attccactgt ttttcctaag tgactaaaaa attacacttt 2881 attcgtctgt gtcctgctct gggatgatag tctgactttc ctaacctgag cctaacatcc 2941 ctgacatcag gaaagactac accatgtgga gaaggggtgg tggttttgat tgctgctgtc 3001 ttcagttaga tggttaactt tgtgaagttg aaaactgtgg ctctctggtt gactgttaga 3061 gttctggcac ttgtcactat gcctattatt taacaaatgc atgaatgctt cagaatatgg 3121 gaatattatc ttctggaata gggaatcaag ttatattatg taacccagga ttagaagatt 3181 cttctgtgtg taagaatttc ataaacatta agctgtctag caaaagcaag ggcttggaaa 3241 atctgtgagc tcctcaccat atagaaagct tttaacccat cattgaataa atccctatag 3301 gggatttcta ccctgagcaa aaggctggtc ttgattaatt cccaaactca tatagctctg 3361 agaaagtcta tgctgttaac gttttcttgt ctgctacccc atcatatgca caacaataaa 3421 tgcaggccta ggcatgactg aaggctctct cataattctt ggttgcatga atcagattat 3481 caacagaaat gttgagacaa actatgggga agcagggtat gaaagagctc tgaatgaaat 3541 ggaaaccgca atgcttcctg cccattcagg gctccagcat gtagaaatct ggggctttgt 3601 gaagactggc ttaaaatcag aagccccatt ggataagagt agggaagaac ctagagccta 3661 cgctgagcag gtttccttca tgtgacaggg agcctcctgc cccgaacttc cagggatcct 3721 ctcttaagtg tttcctgctg gaatctcctc acttctatct ggaaatggtt tctccacagt 3781 ccagcccctg gctagttgaa agagttaccc atgcagaggc cctcctagca tccagagact 3841 agtgcttaga ttcctacttt cagcgttgga caacctggat ccacttgccc agtgttcttc 3901 cttagttcct accttcgacc ttgatcctcc tttatcttcc tgaaccctgc tgagatgatc 3961 tatgtgggga gaatggcttc tttgagaaac atcttcttcg ttagtggcct gcccctcatt 4021 cccactttaa tatccagaat cactataaga agaatataat aagaggaata actcttatta 4081 taggtaaggg aaaattaaga ggcatacgtg atgggatgag taagagagga gagggaagga 4141 ttaatggatg ataaaatcta ctactatttg ttgagacctt ttatagtcta atcaattttg 4201 ctattgtttt ccatcctcac gctaactcca taaaaaaaca ctattattat ctttattttg 4261 ccatgacaag actgagctca gaagagtcaa gcatttgcct aaggtcggac atgtcagagg 4321 cagtgccaga cctatgtgag actctgcagc tactgctcat gggccctgtg ctgcactgat 4381 gaggaggatc agatggatgg ggcaatgaag caaaggaatc attctgtgga taaaggagac 4441 agccatgaag aagtctatga ctgtaaattt gggagcagga gtctctaagg acttggattt 4501 caaggaattt tgactcagca aacacaagac cctcacggtg actttgcgag ctggtgtgcc 4561 agatgtgtct atcagaggtt ccagggaggg tggggtgggg tcagggctgg ccaccagcta 4621 tcagggccca gatgggttat aggctggcag gctcagatag gtggttaggt caggttggtg 4681 gtgctgggtg gagtccatga ctcccaggag ccaggagaga tagaccatga gtagagggca 4741 gacatgggaa aggtggggga ggcacagcat agcagcattt ttcattctac tactacatgg 4801 gactgctccc ctataccccc agctaggggc aagtgccttg actcctatgt tttcaggatc 4861 atcatctata aagtaagagt aataattgtg tctatctcat agggttatta tgaggatcaa 4921 aggagatgca cactctctgg accagtggcc taacagttca ggacagagct atgggcttcc 4981 tatgtatggg tcagtggtct caatgtagca ggcaagttcc agaagatagc atcaaccact 5041 gttagagata tactgccagt ctcagagcct gatgttaatt tagcaatggg ctgggaccct 5101 cctccagtag aaccttctaa ccagctgctg cagtcaaagt cgaatgcagc tggttagact 5161 ttttttaatg aaagcttagc tttcattaaa gattaagctc ctaagcaggg cacagatgaa 5221 attgtctaac agcaactttg ccatctaaaa aaatctgact tcactggaaa catggaagcc 5281 caaggttctg aacatgagaa atttttagga atctgcacag gagttgagag ggaaacaaga 5341 tggtgaaggg actagaaacc acatgagaga cacgaggaaa tagtgtagat ttaggctgga 5401 ggtaaatgaa agagaagtgg gaattaatac ttactgaaat ctttctatat gtcaggtgcc 5461 attttatgat atttaataat ctcattacat atggtaattc tgtgagatat gtattattga 5521 acatactata attaatacta atgataagta acacctcttg agtacttagt atatgctaga 5581 atcaaattta agtttatcat atgaggccgg gcacggtggc tcatatatgg gattacatgc 5641 ctgtaatccc agcactttgg gaggccaagg caattggatc acctgaggtc aggagttcca 5701 gaccagcctg gccaacatgg tgaaacccct tctctactaa aaaatacaaa aaatcagcca 5761 ggtgtggtgg cacgcgtcta taatcccagc tactcaggag gctgaggcag gagaatcact 5821 tgaacccagg aggtggaggt tgcagtgagc taagattgca ccactgcact ccagcctagg 5881 cgacagagtg agactccatc tcaaaaaaaa aaaaagaagt ttattatatg aattaactta 5941 gttttactca caccaatact cagaagtaga ttattacctc atttattgat gaggagccca 6001 atgtacttgt agtgtagatc aacttattga aagcacaagc taataagtag acaattagta 6061 attagaagtc agatggtctg agctctccta ctgtctacat tacatgagct cttattaact 6121 ggggactcga aaatcaaaga catgaaataa tttgtccaag cttacagaac caccaagtag 6181 taaggctagg atgtagaccc agttctgcta cctctgaaga cagtgttttt tccacagcaa 6241 aacacaaact cagatattgt ggatgcgaga aattagaagt agatattcct gccctgtggc 6301 ccttgcttct tacttttact tcttggcgat tggaagttgt ggtccaagcc acagttgcag 6361 accatacttc ctcaaccata attgcatttc ttcaggaaag tttgagggag aaaaaggtaa 6421 agaaaaattt agaaacaact tcagaataaa gagattttct cttgggttac agagattgtc 6481 atatgacaaa ttataagcag acacttgaga aaactgaagg cccatgcctg cccaaattac 6541 cctttgaccc cttggtcaag ctgcaacttt ggttaaaggg agtgtttatg tgttatagtg 6601 ttcatttact cttctggtct aacccattgg ctccgtcttc atcctgcagt gacctcagtg 6661 cctcagaaac atacatatgt ttgtctagtt taagtttgtg tgaaattcta actagcgtca 6721 agaactgagg gccctaaact atgctaggaa tagtgctgtg gtgctgtgat aggtacacaa 6781 gaaatgagaa gaaactgcag attctctgca tctccctttg ccgggtctga caacaaagtt 6841 tccccaaatt ttaccaatgc aagccatttc tccatatgct aactacttta aaatcatttg 6901 gggcttcaca ttgtctttct catctgtaaa aagaatggaa gaactcattc ctacagaact 6961 ccctatgtct tccctgatgg gctagagttc ctctttctca aaaattagcc attattgtat 7021 ttccttctaa gccaaagctc agaggtcttg tattgcccag tgacatgcac actggtcaaa 7081 agtaggctaa gtagaagggt actttcacag gaacagagag caaaagaggt gggtgaatga 7141 gagggtaagt gagaaaagac aaatgagaag ttacaacatg atggcttgtt gtctaaatat 7201 ctcctaggga attattgtga gaggtctgaa tagtgttgta aaataagctg aatctgctgc 7261 ctaacattaa cagtcaagaa atacctccga ataactgtac ctccaattat tctttaaggt 7321 agcatgcaac tgtaatagtt gcatgtatat atttatcata atactgtaac agaaaacact 7381 tactgaatat atactgtgtc cctagttctt tacacaataa actaatctca tcctcataat 7441 tctattagct aatacatatt atcatcctat atttcagaga cttcaagaag ttaagcaact 7501 tgctcaagat catctaagaa gtaggtggta tttctgggct catttggccc ctcctaatct 7561 ctcatggcaa catggctgcc taaagtgttg attgccttaa ttcatcaggg atgggctcat 7621 actcactgca gaccttaact ggcatcctct tttcttatgt gatctgcctg accctagtag 7681 aacttatgaa atttctgatg agaaaggaga gaggagaaag gcagagctga ctgtgatgag 7741 tgatgaaggt gccttctcat ctgggtacca gtggggcctc taagactaag tcactctgtc 7801 tcactgtgtc ttagccagtt ccttacagct tgccctgatg ggagatagag aatgggtatc 7861 ctccaacaaa aaaataaatt ttcatttctc aaggtccaac ttatgttttc ttaattttta 7921 aaaaaatctt gaccattctc cactctctaa aataatccac agtgagagaa acattctttt 7981 cccccatccc ataaatacct ctattaaata tggaaaatct gggcatggtg tctcacacct 8041 gtaatcccag cactttggga ggctgaggtg ggtggactgc ttggagctca ggagttcaag 8101 accatcttgg acaacatggt gataccctgc ctctacaaaa agtacaaaaa ttagcctggc 8161 atggtggtgt gcacctgtaa tcccagctat tagggtggct gaggcaggag aattgcttga 8221 acccgggagg cggaggttgc agtgagctga gatcgtgcca ctgcactcca gcctggggga 8281 cagagcacat tataattaac tgttattttt tacttggact cttgtgggga ataagataca 8341 tgttttattc ttatttatga ttcaagcact gaaaatagtg tttagcatcc agcaggtgct 8401 tcaaaaccat ttgctgaatg attactatac tttttacaag ctcagctccc tctatccctt 8461 ccagcatcct catctctgat taaataagct tcagtttttc cttagttcct gttacatttc 8521 tgtgtgtctc cattagtgac ctcccatagt ccaagcatga gcagttctgg ccaggcccct 8581 gtcggggtca gtgccccacc cccgccttct ggttctgtgt aaccttctaa gcaaaccttc 8641 tggctcaagc acagcaatgc tgagtcatga tgagtcatgc tgaggcttag ggtgtgtgcc 8701 cagatgttct cagcctagag tgatgactcc tatctgggtc cccagcagga tgcttacagg 8761 gcagatggca aaaaaaagga gaagctgacc acctgactaa aactccacct caaacggcat 8821 cataaagaaa atggatgcct gagacagaat gtgacatatt ctagaatata ttatttcctg 8881 aatatatata tatatatata tacacatata cgtatatata tatatatata tatatttgtt 8941 gttatcaatt gccatagaat gattagttat tgtgaatcaa atatttatct tgcaggtggc 9001 ctctatacct agaagcggca gaatcaggct ttattaatac atgtgtatag atttttagga 9061 tctatacaca tgtattaata tgaaacaagg atatggaaga ggaaggcatg aaaacaggaa 9121 aagaaaacaa accttgtttg ccattttaag gcacccctgg acagctaggt ggcaaaaggc 9181 ctgtgctgtt agaggacaca tgctcacata cggggtcaga tctgacttgg ggtgctactg 9241 ggaagctctc atcttaagga tacatctcag gccagtcttg gtgcattagg aagatgtagg 9301 caactctgat cctgagagga aagaaacatt cctccaggag agctaaaagg gttcacctgt 9361 gtgggtaact gtgaaggact acaagaggat gaaaaacaat gacagacaga cataatgctt 9421 gtgggagaaa aaacaggagg tcaaggggat agagaaggct tccagaagaa tggctttgaa 9481 gctggcttct gtaggagttc acagtggcaa agatgtttca gaaatgtgac atgacttaag 9541 gaactataca aaaaggaaca aatttaagga gaggcagata aattagttca acagacatgc 9601 aaggaatttt cagatgaatg ttatgtctcc actgagcttc ttgaggttag cagctgtgag 9661 ggttttgcag gcccaggacc cattacagga cctcacgtat acttgacact gttttttgta 9721 ttcatttgtg aatgaatgac ctcttgtcag tctactcggt ttcgctgtga atgaatgatg 9781 tcttgtcagc ctacttggtt tcgctaagag cacagagaga agatttagtg atgctatgta 9841 aaaacttcct ttttggttca agtgtatgtt tgtgatagaa atgaagacag gctacatgat 9901 gcatatctaa cataaacaca aacattaaga aaggaaatca acctgaagag tatttataca 9961 gataacaaaa tacagagagt gagttaaatg tgtaataact gtggcacagg ctggaatatg 10021 agccatttaa atcacaaatt aattagaaaa aaaacagtgg ggaaaaaatt ccatggatgg 10081 gtctagaaag actagcattg ttttaggttg agtggcagtg tttaaagggt gatatcagac 10141 taaacttgaa atatgtggct aaataactag aatactcttt attttttcgt atcatgaata 10201 gcagatatag cttgatggcc ccatgcttgg tttaacatcc ttgctgttcc tgacatgaaa 10261 tccttaattt ttgacaaagg ggctattcat tttcatttta tattgggcct agaaattatg 10321 tagatggtcc tgaggaaaag tttatagctt gtctatttct ctctctaaca tagttgtcag 10381 cacaatgcct aggctatagg aagtactcaa agcttgttaa attgaattct atccttctta 10441 ttcaattcta cacatggagg aaaaactcat cagggatgga ggcacgcctc taaggaaggc 10501 aggtgtggct ctgcagtgtg attgggtact tgcaggacga agggtggggt gggagtggct 10561 aaccttccat tcctagtgca gaggtcacag cctaaacatc aaattccttg aggtgcggtg 10621 gctcactcct gtaatcacag cagtttggga cgccaaggtg ggcagatcac ttgaggtcag 10681 gagttggaca ccagcccagc caacatagtg aaacctggtc tctgcttaaa aatataaaaa 10741 ttagctggac gtggtgacgg gagcctgtaa tccaactact tgggaggctg aggcaggaga 10801 atcgcttgaa ccggggaggt ggagtttgca ctgagcagag atcatgccat tgcactccag 10861 cctccagagc gagactctgt ctaaagaaaa acgaaaacaa acaaacaaac aaacaaacaa 10921 aacccatcaa attccctgac cgaacagaat tctgtctgat tgttctctga cttatctacc 10981 attttccctc cttaaagaaa ctgtggaact tccttcagct agaggggcct ggctcagaag 11041 cctctggtca gcatccaaga aatacttgat gtcactttgg ctaaaggtat gatgtgtaga 11101 caagctccag agatggtttc tcatttccat atccacccac ccagctttcc aattttaaag 11161 ccaattctga ggtagagact gtgatgaaca aacaccttga caaaattcaa cccaaagact 11221 cactttgcct agcttcaaaa tccttactct gacatatact cacagccaga aattagcatg 11281 cactagagtg tgcatgagtg caacacacac acacaccaat tccatattct ctgtcagaaa 11341 atcctgttgg tttttcgtga aaggatgttt tcagaggctg accccttgcc ttcacctcca 11401 atgctaccac tctggtctaa gtcactgtca ccaccaccta aattatagct gttgactcat 11461 aacaatcttc ctgcttctac cactgcccca ctacaatttc ttcccaatat actatccaaa 11521 ttagtctttt caaaatgtaa gtcatatatg gtcacctctt tgttcaaagt cttctgatag 11581 tttcctatat catttataat aaaaccaaat ccttacaatt ctctacaata gttgttcatg 11641 catatattat gtttattaca gatacgcata tatatagctc tcatataaat aaatatatat 11701 atttatgtgt atgtgtgtag agtgtttttt cttacaactc tatgatgtag gtattattag 11761 tgtcccaaat tttataattt aggacttcta tgatctcatc ttttattctc cccttcaccg 11821 aatctcatcc tacattggcc ttattgatat tccttgaaaa ttctaagcat cttacatctt 11881 tagggtattt acatttgcca ttccctatgc cctaaatatt taatcatagt ttcatataaa 11941 tgggttcctc atcatctatg ggtactctct caggtgttaa ctttatagtg aggactttcc 12001 tgccatacta cttaaagtag cgataccctt tcaccctgtc ctaatcacac tctggccttc 12061 atttcagttt tttttttttc tccatagcac ctaatctcat tggtatataa catgtttcat 12121 ttgcttattt aatgtcaagc tctttccact atcaagtcca tgaaaacagg aactttattc 12181 ctctattctg tttttgtgct gtattcttag caattttaca attttgaatg aaatgaatga 12241 gcagtcaaac acatatacaa ctataattaa aaggatgtat gctgacacat ccactgctat 12301 gcacacacaa agaaatcagt ggagtagagc tggaagcgct aagcctgcat agagctagtt 12361 agccctccgc aggcagagcc ttgatgggat tactgagttc tagaattgga ctcatttgtt 12421 ttgtaggctg agatttgctc ttgaaaactt gttctgacca aaataaaagg ctcaaaagat 12481 gaatatcgaa accagggtgt tttttacact ggaatttata actagagcac tcatgtttat 12541 gtaagcaatt aattgtttca tcagtcaggt aaaagtaaag aaaaactgtg ccaaggcagg 12601 tagcctaatg caatatgcca ctaaagtaaa cattattcca taggtgtcag atatggctta 12661 ttcatccatc ttcatgggaa ggatggcctt ggcctggaca tcagtgttat gtgaggttca 12721 aaacacctct aggctataag gcaacagagc tccttttttt tttttctgtg ctttcctggc 12781 tgtccaaatc tctaatgata agcatacttc tattcaatga gaatattctg taagattata 12841 gttaagaatt gtgggagcca ttccgtctct tatagttaaa tttgagcttc ttttatgatc 12901 actgtttttt taatatgctt taagttctgg ggtacatgtg ccatggtggt ttgctgcacc 12961 catcaacccg tcatctacat taggtatttc tcctaatgct atccttcccc tagcccccca 13021 cccccaacag gccccagtgt gtgatgttcc cctccctgtg tccatggatc actggttttt 13081 tttttttttt tttttttttt tttaaagtct cagttaaatt tttggaatgt aatttatttt 13141 cctggtatcc taggacctgc aagttatctg gtcactttag ccctcacgtt ttgatgataa 13201 tcacatattt gtaaacacaa cacacacaca cacacacaca cacatatata tatataaaac 13261 atatatatac ataaacacac ataacatatt tatcgggcat ttctgagcaa ctaactcatg 13321 caggactctc aaacactaac ctatagcctt ttctatgtat ctacttgtgt agaaaccaag 13381 cgtggggact gagaaggcaa tagcaggagc attctgactc tcactgcctt tggctaggtc 13441 cctccctcat cacagctcag catagtccga gctcttatct atatccacac acagtttctg 13501 acgctgccca gctatcacca tcccaagtct aaagaaaaaa ataatgggtt tgcccatctc 13561 tgttgattag aaaacaaaac aaaataaaat aagcccctaa gctcccagaa aacatgacta 13621 aaccagcaag aagaagaaaa tacaataggt atatgaggag actggtgaca ctagtgtctg 13681 aatgaggctt gagtacagaa aagaggctct agcagcatag tggtttagag gagatgtttc 13741 tttccttcac agatgcctta gcctcaataa gcttgcggtt gtggaagttt actttcagaa 13801 caaactcctg tggggctaga attattgatg gctaaaagaa gcccggggga gggaaaaatc 13861 attcagcatc ctcaccctta gtgacacaaa acagaggggg cctggttttc catatttcct 13921 catgatggat gatctcgtta atgaaggtgg tctgacgaga tcattgcttc ttccatttaa 13981 gccttgctca cttgccaatc ctcagtttta accttctcca gagaaataca cattttttat 14041 tcaggaaaca tactatgtta tagtttcaat actaaataat caaagtactg aagatagcat 14101 gcataggcaa gaaaaagtcc ttagctttat gttgctgttg tttcagaatt taaaaaagat 14161 caccaagtca aggacttctc agttctagca ctagaggtgg aatcttagca tataatcaga 14221 ggtttttcaa aatttctaga catgagattc aaagccctgc acttaaaata gtctcatttg 14281 aattaactct ttatataaat tgaaagcaca ttctgaacta cttcagagta ttgttttatt 14341 tctatgttct tagttcataa atacattagg caatgcaatt taattaaaaa aacccaagaa 14401 tttcttagaa ttttaatcat gaaaataaat gaaggcatct ttacttactc aaggtcccaa 14461 aaggtcaaag aaaccaggaa agtaaagcta tatttcagcg gaaaatggga tatttatgag 14521 ttttctaagt tgacagactc aagttttaac cttcagtgcc catgatgtag gaaagtgtgg 14581 cataactggc tgattctggc tttctactcc tttttcccat taaagatccc tcctgcttaa 14641 ttaacattca caagtaactc tggttgtact ttaggcacag tggctcccga ggtcagtcac 14701 acaataggat gtctgtgctc caagttgcca gagagagaga ttactcttga gaatgagcct 14761 cagccctggc tcaaactcac ctgcaaactt cgtgagagat gaggcagagg tacactacga 14821 aagcaacagt tagaagctaa atgatgagaa cacatggact catagaggga aacaacgcat 14881 actggggcct atcagagggt ggagggtgag agaaggagag gatcaggaaa aatcactaat 14941 ggatgctaag cgtaatacct gagtgatgag atcatctata caacaaaccc ccttgacatt 15001 catttatcta tgtaacaaac ctgcacatcc tgtacacgta cccctgaact taaaataaaa 15061 gttgaaaaca agaaagcaac agtttgaaca cttgttatgg tctattctct cattctttac 15121 aattacacta gaaaatagcc acaggctcct gcaaggcagc cacagaattt atgacttgtg 15181 atatccaagt cattcctgga taatgcaaaa tctaacacaa aatctagtag aatcatttgc 15241 ttacatctat ttttgttctg agaatataga tttagataca taatggaagc agaataattt 15301 aaaatctggc taatttagaa tcctaagcag ctcttttcct atcagtggtt tacaagcctt 15361 gtttatattt ttcctatttt aaaaataaaa ataaagtaag ttatttgtgg taaagaatat 15421 tcattaaagt atttatttct tagataatac catgaaaaac attcagtgaa gtgaagggcc 15481 tactttaccc aacaagaatc taatttatat aatttttcat actaatagca tctaagaaca 15541 gtacaatatt tgactcttca ggttaaacat atgtcataaa ttagccagaa agatttaaga 15601 aaatattgga tgtttccttg tttaaattag gcatcttaca gtttttagaa tcctgcatag 15661 aacttaagaa attacaaatg ctaaagcaaa cccaaacagg caggaattaa tcttcatcga 15721 atttgggtgt ttctttctaa aagtccttta tacttaaatg tcttaagaca tacatagatt 15781 ttattttact aattttaatt atacagacaa taaatgaata ttcttactga ttactttttc 15841 tgactgtcta atctttctga tctatcctgg atggccataa cacttatctc tctgaacttt 15901 gggcttttaa tataggaaag aaaagcaata atccattttt catggtatct catatgataa 15961 acaaataaaa tgcttaaaaa tgagcaggtg aagcaattta tcttgaacca acaagcatcg 16021 aagcaataat gagactgccc gcagcctacc tgacttctga gtcaggattt ataagccttg 16081 ttactgagac acaaacctgg gcctttcaat gctataacct ttcttgaagc tcctccctac 16141 cacctttagc cataaggaaa catggaatgg gtcagatccc tggatgcaag ccaggtctgg 16201 aaccataggc agtaaggaga gaagaaaatg tgggctctgc aactggctcc gagggagcag 16261 gagagaatca accccatact ctgaatctaa gagaagactg gtgtccatac tctgaatggg 16321 aagaatgatg ggattaccca tagggcttgt tttagggaga aacctgttct ccaaactctt 16381 ggccttgaga tacctggtcc ttattccttg gactttggca atgtctgacc ctcacattca 16441 agttctgagg aagggccact gccttcatac tgtggatctg tagcaaattc cccctgaaaa 16501 cccagagctg tatcttaatt gtttaaaaaa attatattat ctcaaggact gttcttctct 16561 gagtagccaa gctcagcttg gttcaagcta caagcagctg agctgctttt tgtctagtca 16621 ttgttctttt atttcagtgg atcaaatacg ttctttccaa acctaggatc ttgtcttcct 16681 aggctatata ttttgtccca ggaagtctta atctggggtc cacagaacac tagggggctg 16741 gtgaagttta tagaaaaaaa atctgtattt ttacttacat gtaactgaaa tttagcattt 16801 tcttctactt tgaatgcaaa ggacaaacta gaatgacatc atcagtacct attgcatagt 16861 tataaagaga aaccacagat attttcatac tacaccatag gtattgcaga tctttttgtt 16921 tttgtttttg tttgagatgg agtttcgctc ttattgccca ggctggagtg cagtggcatg 16981 atttcggctc actgcaacct ccccttcctg cattcaagca attctcctgc cttggcctcc 17041 agagtagctg gggattacag gcacctgcca ccatgccagt ctaatttttg tatttttagt 17101 agagatgggg tttcgccatg ttggccaggc tggtcttgaa ctcctgacct cagatgatct 17161 gcccgccttg gcctcctgaa gtgctgggat tataggtgtg agccaccacg cctggcccat 17221 tgcagatatt tttaattcac atttatctgc atcactactt ggatcttaag gtagctgtag 17281 acccaatcct agatctaatg ctttcataaa gaagcaaata taataaatac tataccacaa 17341 atgtaatgtt tgatgtctga taatgatatt tcagtgtaat taaacttagc actcctatgt 17401 atattatttg atgcaataaa aacatatttt ttttagcact tacagtctgc caaactggcc 17461 tgtgacacaa aaaaagttta ggaattcctg gttttgtctg tgttagccaa tggttagaat 17521 atatgctcag aaagatacca ttggttaata gctgaaagaa aatggagtag aaattcagtg 17581 gcctggaata ataacaattt gggcagtcat taagtcaggt gaagacttct ggaatcatgg 17641 gagaaaagca agggagacat tcttacttgc cacaagtgtt tttttttttt tttttttatc 17701 acaaacataa gaaaatataa taaataacaa agtcaggtta tagaagagag aaacgctctt 17761 agtaaacttg gaatatggaa tccccaaagg cacttgactt gggagacagg agccatactg 17821 ctaagtgaaa aagacgaaga acctctaggg cctgaacata ggaaattgta ggaacagaaa 17881 ttcctagatc tggtggggca aggggagcca taggagaaag aaatggtaga aatggatgga 17941 gacggaggca gaggtgggca gatcatgagg tcaagagatc gagaccatcc tggcaaacat 18001 ggtgaaatcc cgtctctact aaaaataaaa aaattagctg ggcatggtgg catgcgcctg 18061 tagtcccagc tgctcgggag gctgaggcag gagaatcgtt tgaacccagg aggcgaaggt 18121 tgcagtgagc tgagatagtg ccattgcact ccagtctggc aacagagtga gactccgtct 18181 caaaaaaaaa aaaaagaaag aaagaaaaga aaaagaaaaa agaaaaaata aatggatgta 18241 gaacaagcca gaaggaggaa ctgggctggg gcaatgagat tatggtgatg taagggactt 18301 ttatagaatt aacaatgctg gaatttgtgg aactctgctt ctattattcc cccaatcatt 18361 acttctgtca cattgatagt taaataattt ctgtgaattt attccttgat tctaaaatat 18421 gaggataatg acaatggtat tataagggca gattaagtga tatagcataa gcaatattct 18481 tcaggcacat ggatcgaatt gaatacactg taaatcccaa cttccagttt cagctctacc 18541 aagtaaagag ctagcaagtc atcaaaatgg ggacatacag aaaaaaaaaa ggacactaga 18601 ggaataatat accctgactc ctagcctgat taatatatcg attcactttt ttctctgttt 18661 gatgacaaat tctggcttta aataatttta ggattttagg cttctcagct cccttcccag 18721 tgagaagtat aagcaggaca gacaggcaag caagaagaga gccccaggca atactcacaa 18781 agtagccagt gtcccctgtg gtcatagaga aatgaaaaga gagaggattc cctggaagca 18841 ctggatgtaa tcttttctgt ctgtcctctc tagggaatca ccccaaggta ctgtactttg 18901 ggattaaggc tttagtccca ctgtggacta cttgctattc tgttcagttt ctagaaggaa 18961 ctatgtacgg tttttgtctc cctagagaaa ctaaggtaca gaagttttgt ttacaatgca 19021 ctccttaaga gagctagaac tgggtgagat tctgttttaa cagctttatt ttcttttcct 19081 tggccctgtt tttgtcaact gtcaccacct ttaaggcaaa tgttaaatgt gctttggctg 19141 aaactttttt tcctattttg agatttgctc ctttatatga ggctttcttg gaaaaggaga 19201 atgggagaga tggatatcat tttggaagat gatgaagagg gtaaaaaagg ggacaaatgg 19261 aaatttgtgt tgcagataga tgaggagcca acaaaaaaga gcctcaggat ccagcacaca 19321 ttatcacaaa cttagtgtcc atccatcact gctgaccctc tccggacctg actccacccc 19381 tgaggacaca ggtcagcctt gaccaatgac ttttaagtac catggagaac agggggccag 19441 aacttcggca gtaaagaata aaaggccaga cagagaggca gcagcacata tctgcttccg 19501 acacagctgc aatcactagc aagctctcag gcctggcatc atggtgcatt ttactgctga 19561 ggagaaggct gccgtcacta gcctgtggag caagatgaat gtggaagagg ctggaggtga 19621 agccttgggc aggtaagcat tggttctcaa tgcatgggaa tgaagggtga atattaccct 19681 agcaagttga ttgggaaagt cctcaagatt ttttgcatct ctaattttgt atctgatatg 19741 gtgtcatttc atagactcct cgttgtttac ccctggaccc agagattttt tgacagcttt 19801 ggaaacctgt cgtctccctc tgccatcctg ggcaacccca aggtcaaggc ccatggcaag 19861 aaggtgctga cttcctttgg agatgctatt aaaaacatgg acaacctcaa gcccgccttt 19921 gctaagctga gtgagctgca ctgtgacaag ctgcatgtgg atcctgagaa cttcaaggtg 19981 agttcaggtg ctggtgatgt gattttttgg ctttatattt tgacattaat tgaagctcat 20041 aatcttattg gaaagaccaa caaagatctc agaaatcatg ggtcgagctt gatgttagaa 20101 cagcagactt ctagtgagca taaccaaaac ttacatgatt cagaactagt gacagtaaag 20161 gactactaac agcctgaatt ggcttaactt ttcaggaaat cttgccagaa cttgatgtgt 20221 ttatcccaga gaattgtatt atagaattgt agacttgtga aagaagaatg aaatttggct 20281 tttggtagat gaaagtccat ttcaaggaaa tagaaatgcc ttattttatg tgggtcatga 20341 taattgaggt ttagaagaga tttttgcaaa aaaaataaaa gatttgctca aagaaaaata 20401 agacacattt tctaaaatat gttaaatttc ccatcagtat tgtgaccaag tgaaggcttg 20461 tttccgaatt tgttggggat tttaaactcc cgctgagaac tcttgcagca ctcacattct 20521 acatttacaa aaattagaca attgcttaaa gaaaaacagg gagagaggga acccaataat 20581 actggtaaaa tggggaaggg ggtgagggtg taggtaggta gaatgttgaa tgtagggctc 20641 atagaataaa attgaaccta agctcatctg aattttttgg gtgggcacaa accttggaac 20701 agtttgaggt cagggttgtc taggaatgta ggtataaagc cgtttttgtt tgtttgtttg 20761 ttttttcatc aagttgtttt cggaaacttc tactcaacat gcctgtgtgt tattttgtct 20821 tttgcctaac agctcctggg taacgtgatg gtgattattc tggctactca ctttggcaag 20881 gagttcaccc ctgaagtgca ggctgcctgg cagaagctgg tgtctgctgt cgccattgcc 20941 ctggcccata agtaccactg agttctcttc cagtttgcag gtcttcctgt gaccctgaca 21001 ccctccttct gcacatgggg actgggcttg gccttgagag aaagccttct gtttaataaa 21061 gtacattttc ttcagtaatc aaaaattgca attttatctt ctccatcttt tactcttgtg 21121 ttaaaaggaa aaagtgttca tgggctgagg gatggagaga aacataggaa gaaccaagag 21181 cttccttaag aaatgtatgg gggcttgtaa aattaatgtg gatgttatgg gagaattccc 21241 aagattccca aggaggatga tatgatggag aaaaatcttt atcggggtgg gaaaatggtt 21301 aattaagtgg cagagactcc taggcagttt ttactgcacc ggggaaagaa ggagctgttg 21361 tggtacctga gaaagcagat ttgtggtaca tgtcactttt cattaaaaac aaaaacaaaa 21421 caaaacaaaa cttcatagat atccaagata taggctgaga attactattt taatttactc 21481 ttatttacat tttgaagtag ctagcttgtc acatgtttta tgaaattgat ttggagataa 21541 gatgagtgtg tatcaacaat agcctgctct ttccatgaag gattccatta tttcatgggt 21601 tagctgaagc taagacacat gatatcattg tgcattatct tctgatacaa tgtaacatgc 21661 actaaaataa agttagagtt aggacctgag tgggaaagtt tttggagagt gtgatgaaga 21721 ctttccgtgg gagatagaat actaataaag gcttaaattc taaaaccagc aagctagggc 21781 ttcgtgactt gcatgaaact ggctctctgg aagtagaagg gagagtaaga catacgtaga 21841 ggactaggaa agaccagata gtacagggcc tggctacaaa aatacaagct tttactatgc 21901 tattgcaata ctaaacgata agcattagga tgttaagtga ctcaggaaat aagattttgg 21961 gaaaaagtaa tctgcttatg tgcacaaaat ggattcaagt ttgcagataa aataaaatat 22021 ggatgatgat tcaaggggac agatacaatg gttcaaaccc aagaggagca gtgagtctgt 22081 ggaattttga aggatggaca aaggtggggt gagaaagaca tagtattcga cctgactgtg 22141 ggagatgaga aggaagaagg aggtgataaa tgactgaaag ctcccagact ggtgaagata 22201 acaggaggaa accatgcact tgaccctggt gactctcatg tgtgaagggt agagggatat 22261 taacagattt actttttagg aagtgctaga ttggtcaggg agttttgacc ttcaggtctt 22321 gtgtctttca tatcaaggaa cctttgcatt ttccaagtta gagtgccata ttttggcaaa 22381 tataacttta ttagtaattt tatagtgctc tcacattgat cagacttttt cctgtgaatt 22441 acttttgaat ttggctgtat atatccagaa tatgggagag agacaaataa ttattgtagt 22501 tgcaggctat caacaatact ggtctctctg agccttataa cctttcaata tgccccataa 22561 acagagtaaa cagggattat tcatggcact aaatattttc acctaggtca gtcaacaaat 22621 ggaggcaatg tgcatttttt gatacatatt tttatatatt tatggggcat gtgatactta 22681 catgcctaga acatgtgact gattaagtct agatatttag gatatccatt actttgagca 22741 tttatcattt ctatgtattg agaaaatttc aaatcctcat ttctgaccat tttgaaatat 22801 ataataaata gtaattaact atagtcaccc tactcaaata tcaacattat aaactaacta 22861 atccttcttt ccactttttt accaaccaac atctcttaaa tcccctgcca tacacatcac 22921 acatttttca gctctgataa ctatcattct actctcatac caccatgaga ccactttttt 22981 agctccacag atgaataaaa acatgtgata tttgactttc tgtatctggc ttattttatt 23041 atctatctct ttggcatacc aagagtttgt ttttgttctg cttcagggct ttcaattaac 23101 ataatgacct ctggttccat ccatgttgct acaaatgaca agatttcatt ctttttcatg 23161 gcaaaatagt actgtgcaaa aaatacaatt ttttaatccg ttcatctgtt gatagacact 23221 taggttgatc ccaaacctta actattgtga ataggtgctt caataaacat gagtgtaatg 23281 tgtccattgg atatactgat ttcctttctt ttggataaat aaccactagt gagattgctg 23341 gattgtatga tagttctgtt tttagtttat tgagaaatct tcatactgtt ttccataatg 23401 gttgtactat tttacattcc caccaacagt gtgtaagaaa gagttccctt ttctccatat 23461 cctcacaagg atctgttatt ttttgtcttt tttgttaata gcattttaac tagagtaagt 23521 agatatctca ttgtagtttt gatttgcatt tccctgatca ttagtgatgt tgagattttt 23581 tcatatgttt gttggtcatt tgtatatctt tttctgagat tgtctgttca tgtccttatc 23641 ctacttttat tgggattgtt gttattttct tgataatcat tgtgtcattt tagagcctgg 23701 atattattct tttgtcagat gtatagattg tgaagatttt ctcctctgtg ggttgtctgt 23761 ttattctgca gactcttcct tttgccatgc aaaagctctt tagtttaatt tagtcccaga 23821 tattttcttt gtttttatgt gtttgcattt gtgttcttgt catgaaatcc tttcctaagc 23881 caatgtgtag aagggttttt ccgatgttat tttctagaat tgttacagtt tcaggcttag 23941 atttaagtcc ttgatccatc ttaagttgat ttttgtataa ggtgagagat gaagatccag 24001 tttcattctc ctacatgtag cttgccagct atcccgactc atttgttgaa tagggtgccc 24061 tttcccattt atgtttttgt ttgctttgtc aaagatcagt tcggatgtaa gtatttgagt 24121 ttatttctgg gttctctatt ctgttccatt ggtccgatgt gcctatttgt acaccagcat 24181 catgctgtgt ttttggtgac tatggcctta ttgtatagtt tgaaatgagg taatgtaatg 24241 ccattcagat ttgttctttt ttttagactt gcttgtttat tgggctcttt tttggttcca 24301 taagaatttt aggattgttt tttctagttc tgtgaaggct aatggtggta tttatgggaa 24361 ttgcaatgca atttgtaggt tgcttctggc attatggcca ttttcacaat attgattcta 24421 cccatctatg agaatggcat gtgtttccat ttgtttgtgt cttatatgat tactatcagc 24481 cgtgttttgt agttttcctt gtagatgtct ttcacctcct tggttaggta tatattccta 24541 agtttttgtt ttgttttgtt ttgttttttg cagctattgt aaaaggggtt gagttattga 24601 ttttattctc atcttggtca ttgctggtat gtaagaaagc aactcattgg tgtacgttaa 24661 ttttgtatcc agaaactttg ctgaattatt ttatcagttc tagggggttt tggaggagtc 24721 tttagagttt tctacataca caatcatatc atcagcaaac agtgacagtt tgactttctc 24781 tttaacaatt tggatgtgct ttacttgttt ctcttgtctg attgctcttg ctaggacttc 24841 cagtaatatg ttaaagagaa gtggtgagag tgggtatcct tgtctcattc cagttttcag 24901 acagaatgct tttaactttt tcccattcaa tataatgttg gctgtgtgtt taccatagct 24961 ggcttttatt acattgaggt atgtcctttg taaaccgatt ttgctgagtt ttagtcataa 25021 agtgatgttg aattttgttg aatgcagttt ctgtggctat tgagataatc acatgatttt 25081 tgtttccaat tctctttatg ttgtgtatca cacttattga cttgcgtatg ttaaaccatc 25141 cgtgcatccc tcgcatgaaa ccacttgatc atgggttttg atatgccgtg tgggatgcta 25201 ttagctatat tttgtcaagg atgttggcat ctatgttcat cagggatatt gatctgtagt 25261 gttttttttt tttggttatg ttctttccca gttttggtat taaggtgata ctggcttcat 25321 agaatgattt agggaggatt ctctctttct ctatcttgta gaatactgtc aataggattg 25381 gtatcaattc ttctttgaat gtctggtaga attcgaacgt ctcctttagg ttttctagtt 25441 tattcatgta aaggtgttca tagtaacctt gaataatctt ttgtatttct gtggtatcag 25501 taatagtatc tcctgttttg tttctaactg agtttatttg cacttctctc ctcttttctt 25561 ggttaatctt gctaatggtc tatcagtttt atttatcttt tcaaagaacc agctttttat 25621 ttcatttagc ttttgtattt ttttgcagtt gttttaattt catttagttc tcctcttatc 25681 ttagttattc cctttctttt gctgggtttt ggttctgttt gtttttgttt ctctagtttc 25741 ttgtggtgtg accttatatt gtctgtcctc tttcagactc tttgacatcg acatttaggg 25801 ctgtgaactt tccttttagc accatctttg ctgtatccta gaggttttga taggtgtgtc 25861 actattgtcg gtcagttcaa gtaattttgt tgttcttatt atactttaag ttctgggata 25921 catgtgcaga atgtgcaggt ttgttacata ggtatagatg tgccatggtg gtttgctgct 25981 cccatcaacc tgtcatctac attaggtatt tcttttaatg ttatccctct cctaaccccc 26041 tcaccccccg acaggccctg gtgtgtgatg ttcccctccc tgtgtccatg tgttctcatt 26101 gttcaactcc cacttatgag tgagaacgtg tggtgtttgg tttctctgtt cctgtgttag 26161 tttgctcaga atgatgtttc caccttcacc atgtccctgc aaagacatga actcatcatt 26221 ttatggctgc atatattcca tggtgtatat gtgccacatt ttctttatcc attatatcgc 26281 tgatggccat ttgggttggt tccaagtctt tggtattgtg aatagtgccg caataaacat 26341 acgtgtgcac atgtctttat agtagaatga tttctaattc tttgggtata tacccagtaa 26401 tgggattgct gggtcaaaca gtatttctgg ttctagatcc ttgaggaatt gccacactgt 26461 cttccacaat ggttgaacta atttacacac ccatcaacag tgtaaaattt ttcctattct 26521 tccacatcct ctccagcacc ttttgtttcc tgacttttta ataattgcca ttctaactgg 26581 catgagatgg tatctcattg tggttttgat ttgcatttct ctaatgacca gtgatgatga 26641 gcttcttttc atgtgtttct tggccacata aatgacttct ttagagaagc atctgttcat 26701 atcctttgtc cactttttga tggggtcgtt aggttttttc ttgtaaattt gttgaagttc 26761 tttgtagatt ttggatgtta gccctttgtc agatggatag attggcaaaa attttctccc 26821 attctgtagg ttgcctgttc actctgatga tagtcttttg ctgtgcagaa gctctttagt 26881 ttaattagat cccatatgtc aattttggcc tttgttgtca ttgcttttga tgtttagtcg 26941 tggaattttg cccatgccta tgtcctgaat ggtattgcct aggttatctt ctaggatttt 27001 tatggtttta ggttgcacat ttaagtcttt aatccacctt gagttaattt ttgtataagg 27061 tgtaaggaag gggtacagtt tcagttttat gcatattgct agccagtttt tccagcacca 27121 tttattaaat agggaattct ttctccattg cttttgtgat gtttgtcaaa gatcagatgg 27181 tcgtagatgt gtggcattat ttctgaggct tctgttctgt tccactggtc tatatatctg 27241 ttttggtacc agtaccatgc tgtttttgtt actgtagcct tgtagtatag cttgaagtca 27301 ggtagcatca tgcctccagc tttgttcttt ttgtttagga ttgtcttggc tatatgggct 27361 cttttttgat tccatatgac atttaaagta gttttttcta attctttgaa aaaagtcagt 27421 ggtagcttga tggggatagc attgaatcta taaattactt tgggcagtat ggccatttta 27481 aagatattga ttctttctat ctatgagcat ggaatgtttt tccatttgtt tgtgtcctct 27541 cttatttcct tgagcagtga gtggtttgta gctctccttg aagaggttct tcacatccct 27601 tataagttgt atttctaggt attttatttt attctctttg cagcaattgt gaatgggagt 27661 tcacccatga tttggctctc tgcttgtcta ttattggtgt ataggaatgc ttgtgatttt 27721 tgcacactga ttttgtatct tgagactttg ctgaagctgt ttatcagctt aagattttgg 27781 gctgagatga cagggtcttc taaatataca atcatgtcat ctgcaaacag agacaatttg 27841 acttcctctc ttcctatttg aatatgcttt atttctttct cttgcctgat tgtcctggcg 27901 agaacttcca atactatgtt gagtaagagt ggcgagaggg catccttgtc ttgtgccggt 27961 tttcaaagca aatgattttt aaatttccgt cttgatttca ttgttgaccc aatgatcatt 28021 caggagcagg ttatttaatt tccctgtatt tgcatggttt tgaaggttcc ttttgtagtt 28081 gatttccaat tttattctac tgtggtctga gagagtgctt gatataattt caatttttaa 28141 aaatttattg aggcttgttt tgtggcatat catatggcct atcttggaga aagttccatg 28201 tgctgatgaa tagaatgtgt attctgcagt tgttgggtag aatgtcctgt aaatatctgt 28261 taagtccatt tgttctttaa atccattgtt tctttgtaga ctgtcttgat gacctgccta 28321 gtgcagtcag tggagtattg aagtccccca ctattattat gttgctgtct agtagtaatt 28381 gttttataaa tttgggatct ccagtattag atgcatatat attaagaatt gtaatattct 28441 cccattggac aagggctttt atcattatat gatgtccctc tttgtctttt ttaactgctg 28501 tttctttaaa gtttgttttg tctgacataa gaatagctgc tttggctcgc ttttggtgtc 28561 catttgtgtg gaatgtcatt ttccacccct ttaccttaag tttatgtgag tccttatgtg 28621 ttaggtgagt ctcctgaagg cggcagataa ctggttggtg aattctattc attctgcaat 28681 tctgtatctt ttaagtggag catttagtcc atttacattc aacatcagta ttgaggtgtg 28741 aggtgactat tccattcttc gtggtatttg ttgcctgtgt atctttttat ctgtattttt 28801 gttgtatatg tcctatggga tttatgcttt aaagaggttc tgttttgatg tgcttccagg 28861 gtttatttca agatttagag ctccttttat cattcttgta gtgttggctt ggtagtgccg 28921 aattctctca gcatttgttt ttctgaaaaa cactgtgtat tttcttcatt tgtgaagctt 28981 agtttcactg gatataaaat tcttggctga taattgtttt gtttaagaag gctgaagata 29041 gggccatatt cacttctagc ttttacggtt tctgctgaga aatctgctgt taatctgata 29101 ggttttcttt cataggttac ctggtagttt cacctcacag ctcttaagat tctctttgtc 29161 tttagataac tttggatact ctgatgacaa tgtacctagg caatgatatt tttgcaatga 29221 atttcccagg tgtttattga gcttctttgt atttggatat ctaggtctct agcaaggagg 29281 gggaagtttt ccttgattat ttccatggac aagttttcca aacttttaga tttctcttct 29341 ttctcaggaa tgctgattat tcttaggttt gattgtttaa cataatccca gatttcttgg 29401 aggctttgtt catattttct tattcttttt tctttgtctt tgttggattg ggtaattcaa 29461 aaactttgtc ttcaagctct gaatttcttc tgcttggatt ctattgctga gactttctag 29521 agcattttgc atttctataa gtgcatccat tcatccattg tttcctgaag ttttgaatgt 29581 tttttattta tgctatctct ttaactgaag atttctcccc tcatttcttg tatcatattt 29641 ttggtttttt taaaattgga cttcaccttc ctcggatgcc tccttgatta gcttaataac 29701 tgaccttctg aattattttt caggtaaatc agggatttct tcttggtttg gatgcattgc 29761 tggtgagcta gtatgatttt ttggggggtg ttaaagaacc ttgtttttca tattaccaga 29821 gttagttttc tggttccttc tcacttgggt aggctctgtc agagggaaag tctaggcctc 29881 aaggctgaga cttttgtccc agcaggtgtt cccttgatgt agcacagtcc cccttttcct 29941 aggacgtggg gcttcctgag agccgaactg tagtgattgt tatctctctt ctggatctag 30001 ccacccatca ggtctaccag actccaggct ggtactgggg tttgtctgca cagagtcttg 30061 tgacgtgaac catctgtggg tctctcagcc atagatacaa ccacctgctc caatggaggt 30121 ggtagaggat gaaatgaact ctgtgagggt ccttactttt ggttgttcaa tgcactatct 30181 ttttgtgctg gttggcctcc tgccaggagg tggcactttc tagaaagcat cagcagaggc 30241 agtcaggtgg tggtggctgg gggggctggg gcactagaac tcccaagaat atatgccctt 30301 tgtcttcagc tactagggtg agtaaggaag gaccatcagg tgggggcagg actagtcgtg 30361 tctgagctca gagtctcctt gggcaggtct ttctgtggct actgtgggag gatgggggtg 30421 tagtttccag gtcaatggat ttatgttcct aggacaatta tggctgcctc tgctgtgtca 30481 tgcaggtcat caggaaagtg ggggaaagca agcagtcacg tgacttgccc agctcccatg 30541 caactcaaaa ggttggtctc acttccagcg tgcaccctcc cccgcaacag ctccgaatct 30601 gtttccatgc agtcagtgag caaggctgag aacttgccca ggctaccagc tgcgaaacca 30661 agtagggctg tcctacttcc ctgccagtgg agtctgcaca ccaaattcat gtccccccac 30721 caaccccccc actgcccagc ccctagatct ggccaggtgg agattttctt tttcctgtct 30781 cttttcccag ttcctctggc agccctccca aatgacccct gtgaggcaag gcagaaatgg 30841 cttcctaggg gacccagaga gcccacaggg cttttcccgc tgcttcctct acccctgtat 30901 tttgcttggc cctctaaatt gactcagctc caggtaaggt cagaatcttc tcctgtggtc 30961 tagatcttca ggttcccagt gaggatgtgt gtttgggggt agacggtccc ccttttccac 31021 ttccacagtt tgggcactca caatatttgg ggtgtttccc gggtcctaca tgagcaatct 31081 gcttctttca gagggtgtgt gcgttctctc agctttcttg aatttatttc tgcaggtggt 31141 tctgcaaaaa aaattcctga tgggagactt cacatgctgc tctgtgcatc cgagtgggag 31201 ctgcaatgta cttctgctgc cacccatctg ccatcaccct ctaatttgtc ggtaatatgc 31261 atttttaatc aatctttttt tctctctctc tcttttcttc tcccccaaaa ctatactgcc 31321 ctttgatatc aaggaatcaa ggccgtgatg ttgaggggtg ggcagtggat acactcttta 31381 ccccttaggg agcatatcta gatttagata ttgccaattc aagataactt aattgaaagc 31441 aaattcataa tgaatacaca cacacacaca cacatctgca tgacaagatt tttaatagtt 31501 gaaagaataa ctaataattg tccacaggca ataagggctt tttaagcaaa acagttgtga 31561 taaaacaggt cattcttaga atagtaatcc agccaatagt acaggttgct tagagattat 31621 gacattacca gagttaaaat tcaataatgg cttctcactc cctaccactg aggacaagtt 31681 tatgtcctta ggtttatgct tccctgaaac aataccacct gctattctcc actttacata 31741 tcaacggcac tggttcttta tctaactctc tggcacagca ggagtttgtt ttcttctgct 31801 tcagagcttt gaatttacta tttcagcttc taaactttat ttgcaatgcc ttcccatggc 31861 agactccttc tgtcattttg cctctgttcg aaaacttttt ccttaatttc attcttagtt 31921 aataatatct gaaattattt tgttgtttaa cttaattatt aattttatgt atgttctacc 31981 tagatataat cttctagagg attgttttat tctctgactt atttaactta aatgcccact 32041 acctttaaaa attatgacat ttatttaaca gatatttgct gaacaaatgt ttgaaaatac 32101 atgggaaaga atgcttgaaa acacttgaaa ttgcttgtgt aaagaaacag ttttatcagt 32161 taggatttaa tcaatgtcag aagcaatgat ataggaaaaa tcgaggaata agacagttat 32221 ggataaggag aaatcaacaa actcttaaaa gatattgcct caaaagcata agaggaaata 32281 agggtttata catgactttt agaacactgc ctgggttttt ggataaatgg ggaagttgtt 32341 ggaaaacagg agggatccta gatattcctt agtctgagga ggagcaatta agattcactt 32401 gtttagaggc tgggagtggt ggctcacgcc tgtaatccca gaattttggg aggccaaggc 32461 aggcagatca cctgaggtca agagttcaag accaacctgg ccaacatggt gaaatcccat 32521 ctctacaaaa atacaaaaat tagacaggca tgatggcaag tgcctgtaat cccagctact 32581 tgggaggctg aggaaggaga attgcttgaa cctggaaggc aggagttgca gtgagccgag 32641 atcataccac tgcactccag cctgggtgac agaacaagac tctgtctcaa aaaaaaaaaa 32701 gagagattca aaagattcac ttgtttaggc cttagcgggc ttagacacca gtctctgaca 32761 cattcttaaa ggtcaggctc tacaaatgga acccaaccag actctcagat atggccaaag 32821 atctatacac acccatctca cagatcccct atcttaaaga gaccctaatt tgggttcacc 32881 tcagtctcta taatctgtac cagcatacca ataaaaatct ttctcaccca tccttagatt 32941 gagagaagtc acttattatt atgtgagtaa ctggaagata ctgataagtt gacaaatctt 33001 tttctttcct ttcttattca acttttattt taacttccaa agaacaagtg caatatgtgc 33061 agctttgttg cgcaggtcaa catgtatctt tctggtcttt tagccgccta acactttgag 33121 cagatataag ccttacacag gattatgaag tctgaaagga ttccaccaat attattataa 33181 ttcctatcaa cctgataagt taggggaagg tagagctctc ctccaataag ccagatttcc 33241 agagtttctg acgtcataat ctaccaaggt catggatcga gttcagagaa aaaacaaaag 33301 caaaaccaaa cctaccaaaa aataaaaatc ccaaagaaaa aataaagaaa aaaacagcat 33361 gaatacttcc tgccatgtta agtggccaat atgtcagaaa cagcactgag ttacagataa 33421 agatgtctaa actacagtga catcccagct gtcacagtgt gtggactatt agtcaataaa 33481 acagtccctg cctcttaaga gttgttttcc atgcaaatac atgtcttatg tcttagaata 33541 agattcccta agaagtgaac ctagcattta tacaagataa ttaattctaa tccatagtat 33601 ctggtaaaga gcattctacc atcatcttta ccgagcatag aagagctaca ccaaaaccct 33661 gggtcatcag ccagcacata cacttatcca gtgataaata cacatcatcg ggtgcctaca 33721 tacatacctg aatataaaaa aaatactttt gctgagatga aacaggcgtg atttatttca 33781 aataggtacg gataagtaga tattgaagta aggattcagt cttatattat attacataac 33841 attaatctat tcctgcactg aaactgttgc tttataggat ttttcactac actaatgaga 33901 acttaagaga taatggccta aaaccacaga gagtatattc aagaataagt atagcacttc 33961 ttatttggaa accaatgctt actaaatgag actaagacgt gtcccatcaa aaatcctgga 34021 cctatgccta aaacacattt cacaatccct gaacttttca aaaattggta catgctttaa 34081 ctttaaacta caggcctcac tggagctaca gacaagaagg tgaaaaacgg ctgacaaaag 34141 aagtcctggt atcttctatg gtgggagaag aaaactagct aaagggaaga ataaattaga 34201 gaaaaattgg aatgactgaa tcggaacaag gcaaaggcta taaaaaaaat taagcagcag 34261 tatcctcttg ggggcccctt ccccacacta tctcaatgca aatatctgtc tgaaacggtt 34321 cctggctaaa ctccacccat gggttggcca gccttgcctt gaccaatagc cttgacaagg 34381 caaacttgac caatagtctt agagtatcca gtgaggccag gggccggcgg ctggctaggg 34441 atgaagaata aaaggaagca cccttcagca gttccacaca ctcgcttctg gaacgtctga 34501 ggttatcaat aagctcctag tccagacgcc atgggtcatt tcacagagga ggacaaggct 34561 actatcacaa gcctgtgggg caaggtgaat gtggaagatg ctggaggaga aaccctggga 34621 aggtaggctc tggtgaccag gacaagggag ggaaggaagg accctgtgcc tggcaaaagt 34681 ccaggtcgct tctcaggatt tgtggcacct tctgactgtc aaactgttct tgtcaatctc 34741 acaggctcct ggttgtctac ccatggaccc agaggttctt tgacagcttt ggcaacctgt 34801 cctctgcctc tgccatcatg ggcaacccca aagtcaaggc acatggcaag aaggtgctga 34861 cttccttggg agatgccata aagcacctgg atgatctcaa gggcaccttt gcccagctga 34921 gtgaactgca ctgtgacaag ctgcatgtgg atcctgagaa cttcaaggtg agtccaggag 34981 atgtttcagc actgttgcct ttagtctcga ggcaacttag acaactgagt attgatctga 35041 gcacagcagg gtgtgagctg tttgaagata ctggggttgg gagtgaagaa actgcagagg 35101 actaactggg ctgagaccca gtggcaatgt tttagggcct aaggagtgcc tctgaaaatc 35161 tagatggaca actttgactt tgagaaaaga gaggtggaaa tgaggaaaat gacttttctt 35221 tattagattt cggtagaaag aactttcacc tttcccctat ttttgttatt cgttttaaaa 35281 catctatctg gaggcaggac aagtatggtc gttaaaaaga tgcaggcaga aggcatatat 35341 tggctcagtc aaagtgggga actttggtgg ccaaacatac attgctaagg ctattcctat 35401 atcagctgga cacatataaa atgctgctaa tgcttcatta caaacttata tcctttaatt 35461 ccagatgggg gcaaagtatg tccaggggtg aggaacaatt gaaacatttg ggctggagta 35521 gattttgaaa gtcagctctg tgtgtgtgtg tgtgtgtgtg cgcgcgtgtg tttgtgtgtg 35581 tgtgagagcg tgtgtttctt ttaacgtttt cagcctacag catacagggt tcatggtggc 35641 aagaagataa caagatttaa attatggcca gtgactagtg ctgcaagaag aacaactacc 35701 tgcatttaat gggaaagcaa aatctcaggc tttgagggaa gttaacatag gcttgattct 35761 gggtggaagc ttggtgtgta gttatctgga ggccaggctg gagctctcag ctcactatgg 35821 gttcatcttt attgtctcct ttcatctcaa cagctcctgg gaaatgtgct ggtgaccgtt 35881 ttggcaatcc atttcggcaa agaattcacc cctgaggtgc aggcttcctg gcagaagatg 35941 gtgactggag tggccagtgc cctgtcctcc agataccact gagctcactg cccatgatgc 36001 agagctttca aggataggct ttattctgca agcaatacaa ataataaatc tattctgcta 36061 agagatcaca catggttgtc ttcagttctt ttttttatgt ctttttaaat atatgagcca 36121 caaagggttt tatgttgagg gatgtgttta tgtgtattta tacatggcta tgtgtgtttg 36181 tgtcatgtgc acactccaca cttttttgtt tacgttagat gtgggttttg atgagcaaat 36241 aaaagaacta ggcaataaag aaacttatac atgggagcgt ctgcaagtgg gagtaaaagg 36301 tgcaggagaa atctggttgg aagaaagacc tctataggac aggactcctc agaaacagat 36361 gttttggaag agatggggaa aggttcagtg aagggggctg aacccccttc cctggattgc 36421 agcacagcag cgaggaaggg gctcaacgaa gaaaaagtgt tccaagcttt aggaagtcaa 36481 ggtttaggca gggatagcca ttctatttta ttaggggcaa tactatttcc aacggcatct 36541 ggcttttctc agcccttgtg aggctctacg gggaggttga ggtgttagag atcagagcag 36601 gaaacaggtt tttctttcca cggtaactac aatgaagtga tccttacttt actaaggaac 36661 tttttcattt taagtgttga cgcatgccta aagaggtgaa attaatccca tacccttaag 36721 tctacagact ggtcacagca tttcaaggag gagacctcat tgtaagcttc tagggaggtg 36781 gggacctagg tgaaggaaat gagccagcag aagctcacaa gtcagcatca gcgtgtcatg 36841 tctcagcagc agaacagcac ggtcagatga aaatatagtg tgaagaattt gtataacatt 36901 aattgagaag gcagattcac tggagttctt atataattga aagttaatgc acgttaataa 36961 gcaagagttt agtttaatgt gatggtgtta tgaacttaac gcttgtgtct ccagaaaatt 37021 cacatgctga atccccaact cccaattggc tccatttgtg ggggaggctt tggaaaagta 37081 atcaggttta gaggagctca tgagagcaga tccccatcat agaattattt tcctcatcag 37141 aagcagagag attagccatt tctcttcctt ctggtgagga cacagtggga agtcagccac 37201 ctgcaaccca ggaagagagc cctgaccagg aaccagcaga aaagtgagaa aaaatcctgt 37261 tgttgaagtc acccagtcta tgctattttg ttatagcacc ttgcactaag taaggcagat 37321 gaagaaagag aaaaaaataa gcttcggtgt tcagtggatt agaaaccatg tttatctcag 37381 gtttacaaat ctccacttgt cctctgtgtt tcagaataaa ataccaactc tactactctc 37441 atctgtaaga tgcaaatagt aagcctgatc ccttctgtct aacttcgaat tctatttttt 37501 cttcaacgta ctttaggctt gtaatgtgtt tatatacagt gaaatgtcaa gttctttctt 37561 tatatttctt tctttctttt ttttcctcag cctcagagtt ttccacatgc ccttcctacc 37621 ttcaggaact tctttctcca aacgtcttct gcctggcctc cattcaaatc ataaaggacc 37681 cacttcaaat gccatcactc actaccattt cacaattcgc actttctttc tttgtccttt 37741 ttttttttag taaaacaagt ttataaaaaa ttgaaggaat aaatgaatgg ctacttcata 37801 ggcagagtag acacaagggc tactggttgc cgatttttat tgttattttt caatagtatg 37861 ctaaacaagg ggtagattat ttatgctgcc catttttaga ccataaaaga taacttcctg 37921 atgttgccat ggcatttttt ttccttttaa ttttatttca tttcatttta atttcgaagg 37981 tacatgtgca ggatgtgcag gcttgttaca tgggtaaatg tgtgtctttc tggcctttta 38041 gccatctgta tcaatgagca gatataagct ttacacagga tcatgaagga tgaaagaatt 38101 tcaccaatat tataataatt tcaatcaacc tgatagctta ggggataaac taatttgaag 38161 atacagcttg cctccgataa gccagaattc cagagcttct ggcattataa tctagcaagg 38221 ttagagatca tggatcactt tcagagaaaa acaaaaacaa actaaccaaa agcaaaacag 38281 aaccaaaaaa cctccataaa tacttcctac ccagttaatg gtccaatatg tcagaaacag 38341 cactgtgtta gaaataaagc tgtctaaagt acactaatat tcgagttata atagtgtgtg 38401 gactattagt caataaaaac aacccttgcc tctttagagt tgttttccat gtacacgcac 38461 atcttatgtc ttagagtaag attccctgag aagtgaacct agcatttata caagataatt 38521 aattctaatc cacagtacct gccaaagaac attctaccat catctttact gagcatagaa 38581 gagctacgcc aaaaccctgg gtcatcagcc agcacacaca cttatccagt ggtaaataca 38641 catcatctgg tgtatacata catacctgaa tatggaatca aatatttttc taagatgaaa 38701 cagtcatgat ttatttcaaa taggtacgga taagtagata ttgaggtaag cattaggtct 38761 tatattatgt aacactaatc tattactgcg ctgaaactgt ggtctttatg aaaattgttt 38821 tcactacact attgagaaat taagagataa tggcaaaagt cacaaagagt atattcaaaa 38881 agaagtatag cactttttcc ttagaaacca ctgctaactg aaagagacta agatttgtcc 38941 cgtcaaaaat cctggaccta tgcctaaaac acatttcaca atccctgaac ttttcaaaaa 39001 ttggtacatg ctttagcttt aaactacagg cctcactgga gctacagaca agaaggtaaa 39061 aaacggctga caaaagaagt cctggtatcc tctatgatgg gagaaggaaa ctagctaaag 39121 ggaagaataa attagagaaa aactggaatg actgaatcgg aacaaggcaa aggctataaa 39181 aaaaattaag cagcagtatc ctcttggggg ccccttcccc acactatctc aatgcaaata 39241 tctgtctgaa acggtccctg gctaaactcc acccatgggt tggccagcct tgccttgacc 39301 aatagccttg acaaggcaaa cttgaccaat agtcttagag tatccagtga ggccaggggc 39361 cggcggctgg ctagggatga agaataaaag gaagcaccct tcagcagttc cacacactcg 39421 cttctggaac gtctgagatt atcaataagc tcctagtcca gacgccatgg gtcatttcac 39481 agaggaggac aaggctacta tcacaagcct gtggggcaag gtgaatgtgg aagatgctgg 39541 aggagaaacc ctgggaaggt aggctctggt gaccaggaca agggagggaa ggaaggaccc 39601 tgtgcctggc aaaagtccag gtcgcttctc aggatttgtg gcaccttctg actgtcaaac 39661 tgttcttgtc aatctcacag gctcctggtt gtctacccat ggacccagag gttctttgac 39721 agctttggca acctgtcctc tgcctctgcc atcatgggca accccaaagt caaggcacat 39781 ggcaagaagg tgctgacttc cttgggagat gccataaagc acctggatga tctcaagggc 39841 acctttgccc agctgagtga actgcactgt gacaagctgc atgtggatcc tgagaacttc 39901 aaggtgagtc caggagatgt ttcagcactg ttgcctttag tctcgaggca acttagacaa 39961 ctgagtattg atctgagcac agcagggtgt gagctgtttg aagatactgg ggttgggagt 40021 gaagaaactg cagaggacta actgggctga gacccagtgg caatgtttta gggcctaagg 40081 agtgcctctg aaaatctaga tggacaactt tgactttgag aaaagagagg tggaaatgag 40141 gaaaatgact tttctttatt agatttcggt agaaagaact ttcacctttc ccctattttt 40201 gttattcgtt ttaaaacatc tatctggagg caggacaagt atggtcgtta aaaagatgca 40261 ggcagaaggc atatattggc tcagtcaaag tggggaactt tggtggccaa acatacattg 40321 ctaaggctat tcctatatca gctggacaca tataaaatgc tgctaatgct tcattacaaa 40381 cttatatcct ttaattccag atgggggcaa agtatgtcca ggggtgagga acaattgaaa 40441 catttgggct ggagtagatt ttgaaagtca gctctgtgtg tgtgtgtgtg tgtgtgtgtg 40501 tcagcgtgtg tttcttttaa cgtcttcagc ctacaacata cagggttcat ggtgggaaga 40561 agatagcaag atttaaatta tggccagtga ctagtgcttg aaggggaaca actacctgca 40621 tttaatggga aggcaaaatc tcaggctttg agggaagtta acataggctt gattctgggt 40681 ggaagctggg tgtgtagtta tctggaggcc aggctggagc tctcagctca ctatgggttc 40741 atctttattg tctcctttca tctcaacagc tcctgggaaa tgtgctggtg accgttttgg 40801 caatccattt cggcaaagaa ttcacccctg aggtgcaggc ttcctggcag aagatggtga 40861 ctgcagtggc cagtgccctg tcctccagat accactgagc ctcttgccca tgattcagag 40921 ctttcaagga taggctttat tctgcaagca atacaaataa taaatctatt ctgctgagag 40981 atcacacatg attttcttca gctctttttt ttacatcttt ttaaatatat gagccacaaa 41041 gggtttatat tgagggaagt gtgtatgtgt atttctgcat gcctgtttgt gtttgtggtg 41101 tgtgcatgct cctcatttat ttttatatga gatgtgcatt ttgatgagca aataaaagca 41161 gtaaagacac ttgtacacgg gagttctgca agtgggagta aatggtgttg gagaaatccg 41221 gtgggaagaa agacctctat aggacaggac ttctcagaaa cagatgtttt ggaagagatg 41281 ggaaaaggtt cagtgaagac ctgggggctg gattgattgc agctgagtag caaggatggt 41341 tcttaatgaa gggaaagtgt tccaagcttt aggaattcaa ggtttagtca ggtgtagcaa 41401 ttctatttta ttaggaggaa tactatttct aatggcactt agcttttcac agcccttgtg 41461 gatgcctaag aaagtgaaat taatcccatg ccctcaagtg tgcagattgg tcacagcatt 41521 tcaagggaga gacctcattg taagactctg ggggaggtgg ggacttaggt gtaagaaatg 41581 aatcagcaga ggctcacaag tcagcatgag catgttatgt ctgagaaaca gaccagcact 41641 gtgagatcaa aatgtagtgg gaagaatttg tacaacatta attggaaggt ttacttaatg 41701 gaatttttgt atagttggat gttagtgcat ctctataagt aagagtttaa tatgatggtg 41761 ttacggacct ggtgtttgtg tctcctcaaa attcacatgc tgaatcccca actcccaact 41821 gaccttatct gtgggggagg cttttgaaaa gtaattaggt ttagctgagc tcataagagc 41881 agatccccat cataaaatta ttttccttat cagaagcaga gagacaagcc atttctcttt 41941 cctcccggtg aggacacagt gagaagtccg ccatctgcaa tccaggaaga gaaccctgac 42001 cacgagtcag ccttcagaaa tgtgagaaaa aactctgttg ttgaagccac ccagtctttt 42061 gtattttgtt atagcacctt acactgagta aggcagatga agaaggagaa aaaaataagc 42121 ttgggttttg agtgaactac agaccatgtt atctcaggtt tgcaaagctc ccctcgtccc 42181 ctatgtttca gcataaaata cctactctac tactctcatc tataagaccc aaataataag 42241 cctgcgccct tctctctaac tttgatttct cctattttta cttcaacatg ctttactcta 42301 gccttgtaat gtctttacat acagtgaaat gtaaagttct ttattctttt tttctttctt 42361 tcttttttct cctcagcctc agaatttggc acatgccctt ccttctttca ggaacttctc 42421 caacatctct gcctggctcc atcatatcat aaaggtccca cttcaaatgc agtcactacc 42481 gtttcaggat atgcactttc tttctttttt gttttttgtt ttttttaagt caaagcaaat 42541 ttcttgagag agtaaagaaa taaacgaatg actactgcat aggcagagca gccccgaggg 42601 ccgctggttg ttccttttat ggttatttct tgatgatatg ttaaacaagt tttggattat 42661 ttatgccttc tctttttagg ccatataggg taactttctg acattgccat ggcatgtttc 42721 ttttaattta atttactgtt accttaaatt caggggtaca cgtacaggat atgcaggttt 42781 gttttatagg taaaagtgtg ccatggtttt aatgggtttt ttttttcttg taaagttgtt 42841 taagtttctt gtttactctg gatattggcc tttgtcagaa gaatagattg gaaaatcttt 42901 ttcccattct gtagattgtc tttcgctctg atggtagttt cttttgctga gcaggagctc 42961 tttagtttaa ttagattcca ttggtcaatt tttgcttttg ctgcaattgc ttttcacgct 43021 ttcatcatga aatctgtgcc cgtgtttata tcatgaatag tattgccttg atttttttct 43081 aggcttttta tagtttgggg tttttcattt aagtctctaa tccatccgga gttaattttg 43141 gataaggtat aaggaaggag tccagtttca tttttcagca tatggctagc cagttctccc 43201 ccatcattta ttaaattgaa aatcctttcc ccattgcttg cttttgtcag gtttctaaaa 43261 gacagatggt tgtaggtaca atatgcagtt tcttcaagtc atataatacc atctgaaatc 43321 tcttattaat tcatttcttt tagtatgtat gctggtctcc tctgctcact atagtgaggg 43381 caccattagc cagagaatct gtctgtctag ttcatgtaag attctcagaa ttaagaaaaa 43441 tggatggcat atgaatgaaa cttcatggat gacatatgga atctaatgtg tatttgttga 43501 attaatgcat aagatgcaac aagggaaagg ttgacaactg cagtgataac ctggtattga 43561 tgatataaga gtctatagat cacagtagaa gcaataatca tggaaaacaa ttggaaatgg 43621 ggaacagcca caaacaagaa agaatcaata ctaccaggaa agtgactgca ggtcactttt 43681 cctggagcgg gtgagagaaa agtggaagtt gcagtaactg ccgaattcct ggttggctga 43741 tggaaagatg gggcaactgt tcactggtac gcagggtttt agatgtatgt acctaaggat 43801 atgaggtatg gcaatgaaca gaaattcttt tgggaatgag ttttagggcc attaaaggac 43861 atgacctgaa gtttcctctg aggccagtcc ccacaactca atataaatgt gtttcctgca 43921 tatagtcaaa gttgccactt ctttttcttc atatcatcga tctctgctct taaagataat 43981 cttggttttg cctcaaactg tttgtcacta caaactttcc ccatgttcct aagtaaaaca 44041 ggtaactgcc tctcaactat atcaagtaga ctaaaatatt gtgtctctaa tatcagaaat 44101 tcagctttaa tatattgggt ttaactcttt gaaatttaga gtctccttga aatacacatg 44161 ggggtgattt cctaaacttt atttcttgta aggatttatc tcaggggtaa cacacaaacc 44221 agcatcctga acctctaagt atgaggacag taagccttaa gaatataaaa taaactgttc 44281 ttctctctgc cggtggaagt gtgccctgtc tattcctgaa attgcttgtt tgagacgcat 44341 gagacgtgca gcacatgaga cacgtgcagc agcctgtgga atattgtcag tgaagaatgt 44401 ctttgcctga ttagatataa agacaagtta aacacagcat tagactatag atcaagcctg 44461 tgccagacac aaatgaccta atgcccagca cgggccacgg aatctcctat cctcttgctt 44521 gaacagagca gcacacttct cccccaacac tattagatgt tctggcataa ttttgtagat 44581 atgtaggatt tgacatggac tattgttcaa tgattcagag gaaatctcct ttgttcagat 44641 aagtacactg actactaaat ggattaaaaa acacagtaat aaaacccagt tttcccctta 44701 cttccctagt ttgtttctta ttctgctttc ttccaagttg atgctggata gaggtgttta 44761 tttctattct aaaaagtgat gaaattggcc gggcgcggtg gctcacacct gtaatcccag 44821 cactttggga ggctgaggtg ggcggatcac gaggtcagga gatcaagacc atcctggcta 44881 acatggtgaa accccatctc tactaaaaat acaaaaaatt agccagagac ggtggcgggt 44941 gcctgtagtc ccagctactc gggaggctga ggcaggagaa tggcgtgaac ctgggaggca 45001 gagctgcagt gagcagagat cgcgccactg cacactccag cctgggtgac aaagcgagac 45061 tccatctcaa aaaaaaaaaa aaaaaaaaaa agaaagaaag aaagaaaaaa aaagtgatga 45121 aattgtgtat tcaatgtagt ctcaagagaa ttgaaaacca agaaaggctg tggcttcttc 45181 cacataaagc ctggatgaat aacaggataa cacgttgtta cattgtcaca actcctgatc 45241 caggaattga tggctaagat attcgtaatt cttatccttt tcagttgtaa cttattccta 45301 tttgtcagca ttcaggttat tagcggctgc tggcgaagtc cttgagaaat aaactgcaca 45361 ctggatggtg ggggtagtgt aggaaaatgg aggggaagga agtaaagttt caaattaagc 45421 ctgaacagca aagttcccct gagaaggcca cctggattct atcagaaact cgaatgtcca 45481 tcttgcaaaa cttccttgcc caaaccccac ccctggagtc acaacccacc cttgaccaat 45541 agattcattt cactgaggga ggcaaagggc tggtcaatag attcatttca ctgggagagg 45601 caaagggctg ggggccagag aggagaagta aaaagccaca catgaagcag caatgcaggc 45661 atgcttctgg ctcatctgtg atcaccagga aactcccaga tctgacactg tagtgcattt 45721 cactgctgac aagaaggctg ctgccaccag cctgtgaagc aaggttaagg tgagaaggct 45781 ggaggtgaga ttctgggcag gtaggtactg gaagccggga caaggtgcag aaaggcagaa 45841 agtgtttctg aaagagggat tagcccgttg tcttacatag tctgactttg cacctgctct 45901 gtgattatga ctatcccaca gtctcctggt tgtctaccca tggacctaga ggtactttga 45961 aagttttgga tatctgggct ctgactgtgc aataatgggc aaccccaaag tcaaggcaca 46021 tggcaagaag gtgctgatct ccttcggaaa agctgttatg ctcacggatg acctcaaagg 46081 cacctttgct acactgagtg acctgcactg taacaagctg cacgtggacc ctgagaactt 46141 cctggtgagt agtaagtaca ctcacgcttt cttctttacc cttagatatt tgcactatgg 46201 gtacttttga aagcagaggt ggctttctct tgtgttatga gtcagctatg ggatatgata 46261 tttcagcagt gggattttga gagttatgtt gctgtaaata acataactaa aatttggtag 46321 agcaaggact atgaataatg gaaggccact taccatttga tagctctgaa aaacacatct 46381 tataaaaaat tctggccaaa atcaaactga gtgttttgga tgagggaaca gaagttgaga 46441 tagagaaaat aacatctttc ctttggtcag cgaaattttc tataaaaatt aatagtcact 46501 tttctgcata gtcctggagg ttagaaaaag atcaactgaa caaagtagtg ggaagctgtt 46561 aaaagaggat tgtttccctc cgaatgatga tggtatactt ttgtacgcat ggtacaggat 46621 tctttgttat gagtgtttgg gaaaattgta tgtatgtatg tatgtatgtg atgactgggg 46681 acttatccta tccattactg ttccttgaag tactattatc ctacttttta aaaggacgaa 46741 gtctctaaaa aaaaaatgaa acaatcacaa tatgttgggg tagtgagttg gcatagcaag 46801 taagagaagg ataggacaca atgggaggtg cagggctgcc agtcatattg aagctgatat 46861 ctagcccata atggtgagag ttgctcaaac tctggtcaaa aaggatgtaa gtgttatatc 46921 tatttactgc aagtccagct tgaggccttc tattcactat gtaccatttt cttttttatc 46981 ttcactccct ccccagctct taggcaacgt gatattgatt gttttggcaa cccacttcag 47041 cgaggatttt accctacaga tacaggcttc ttggcagtaa ctaacaaatg ctgtggttaa 47101 tgctgtagcc cacaagacca ctgagttccc tgtccactat gtttgtacct atgtcccaaa 47161 atctcatctc ctttagatgg gggaggttgg ggagaagagc agtatcctgc ctgctgattc 47221 agttcctgca tgataaaaat agaataaaga aatatgctct ctaagaaata tcattgtact 47281 ctttttctgt ctttatattt taccctgatt cagccaaaag gacgcactat ttctgatgga 47341 aatgagaatg ttggagaatg ggagtttaag gacagagaag atactttctt gcaatcctgc 47401 aagaaaagag agaactcgtg ggtggattta gtggggtagt tactcctagg aaggggaaat 47461 cgtctctaga ataagacaat gtttttacag aaagggaggt caatggaggt actctttgga 47521 ggtgtaagag gattgttggt agtgtgtaga ggtatgttag gactcaaatt agaagttctg 47581 tataggctat tatttgtatg aaactcagga tatagctcat ttggtgactg cagttcactt 47641 ctacttattt taaacaacat attttttatg atttataatg aagtggggat ggggcttcct 47701 agagaccaat caagggccaa accttgaact ttctcttaac gtcttcaatg gtattaatag 47761 agaattatct ctaaggcatg tgaactggct gtcttggttt tcatctgtac ttcatctgct 47821 acctctgtga cctgaaacat atttataatt ccattaagct gtgcatatga tagatttatc 47881 atatgtattt tccttaaagg atttttgtaa gaactaattg aattgatacc tgtaaagtct 47941 ttatcacact acccaataaa taataaatct ctttgttcag ctctctgttt ctataaatat 48001 gtacaagttt tattgttttt agtggtagtg attttattct ctttctatat atatacacac 48061 acatgtgtgc attcataaat atatacaatt tttatgaata aaaaattatt agcaatcaat 48121 attgaaaacc actgattttt gtttatgtga gcaaacagca gattaaaagg ctgagattta 48181 ggaaacagca cgttaagtca agttgataga ggagaatatg gacatttaaa agaggcagga 48241 tgatataaaa ttagggaaac tggatgcaga gaccagatga agtaagaaaa atagctatcg 48301 ttttgagcaa aaatcactga agtttcttgc atatgagagt gacataataa atagggaaac 48361 gtagaaaatt gattcacatg tatatatata tatagaactg attagacaaa gtctaacttg 48421 ggtatagtca gaggagcttg ctgtaattat attgaggtga tggataaaga actgaagttg 48481 atggaaacaa tgaagttaag aaaaaaaatc gagtaagaga ccattgtggc agtgattgca 48541 cagaactgga aaacattgtg aaacagagag tcagagatga cagctaaaat ccctgtctgt 48601 gaatgaaaag aaggaaattt attgacagaa cagcaaatgc ctacaagccc cctgtttgga 48661 tctggcaatg aacgtagcca ttctgtggca atcacttcaa actcctgtac ccaagaccct 48721 taggaagtat gtagcaccct caaacctaaa acctcaaaga aagaggtttt agaagatata 48781 ataccctttc ttctccagtt tcattaatcc caaaacctct ttctcaaagt atttcctcta 48841 tgtgtccacc ccaaagagct cacctcacca tatctcttga gtgggagcac atagataggc 48901 ggtgctacca tctaacagct tctgaaattc ctttgtcata tttttgagtc cccactaata 48961 acccacaaag cagaataaat accagttgct catgtacaat aatcactcaa ctgctgtctt 49021 gtagcataca ttaattaagc acattctttg aataattact gtgtccaaac aatcacactt 49081 taaaatctca cacttgtgct atcccttgcc cttctgaatg tcactctgta ttttaaatga 49141 agagatgagg gttgaatttc ctgtgttact tattgttcat ttctcgatga ggagttttca 49201 cattcacctt tactggaaaa cacataagta cacatcttac aggaaaaata taccaaactg 49261 acatgtagca tgaatgcttg tgcatgtagt catataaaat cttgtagcaa tgtaaacatt 49321 ctctgatata cacatacaga tgtgtctata tgtctacaca atttcttatg ctccatgaac 49381 aaacattcca tgcacacata agaacacaca ctgttacaga tgcatacttg agtgcattga 49441 caaaattacc ccagtcaatc tagagaattt ggatttctgc atttgactct gttagctttg 49501 tacatgctgt tcatttactc tgggtgatgt ctttccctca ttttgccttg tctatcttgt 49561 actcatactt taagtcctaa cttatatgtt atctcaacta agaagctatt tttttttaat 49621 tttaactggg cttaaagccc tgtctataaa ctctgctaca attatgggct ctttcttata 49681 atatttagtg tttttcctac taatgtactt aatctgctca ttgtatattc ctaccactaa 49741 attttaacct cttttatggt agagacattg tcttgtaaac tcttatttcc ctagtatttg 49801 gagatgaaaa aaaagattaa attatccaaa attagatctc tcttttctac attatgagta 49861 ttacactatc catagggaag tttgtttgag acctaaactg aggaaccttt ggttctaaaa 49921 tgactatgtg atatcttagt atttataggt catgaggttc cttcctctgc ctctgctata 49981 gtttgattag tcagcaagca tgtgtcatgc atttattcac atcagaattt catacactaa 50041 taagacatag tatcagaagt cagtttatta gttatatcag ttagggtcca tcaaggaaag 50101 gacaaaccat tatcagttac tcaacctaga attaaataca gctcttaata gttaattatc 50161 cttgtattgg aagagctaaa atatcaaata aaggacagtg cagaaatcta gatgttagta 50221 acatcagaaa acctcttccg ccattaggcc tagaagggca gaaggagaaa atgtttatac 50281 caccagagtc cagaaccaga gcccataacc agaggtccac tggattcagt gagctagtgg 50341 gtgctccttg gagagagcca gaactgtcta atgggggcat caaagtatca gccataaaaa 50401 accataaaaa agactgtctg ctgtaggaga tccgttcaga gagagagaga gaccagaaat 50461 aatcttgctt atgctttccc tcagccagtg tttaccattg cagaatgtac atgcgactga 50521 aagggtgagg aaacctggga aatgtcagtt cctcaaatac agagaacact gagggaagga 50581 tgagaaataa atgtgaaagc agacatgaat ggtaattgac agaaggaaac taggatgtgt 50641 ccagtaaatg aataattaca gtgtgcagtg attattgcaa tgattaatgt attgataaga 50701 taatatgaaa acacagaatt caaacagcag tgaactgaga ttagaattgt ggagagcact 50761 ggcatttaag aatgtcacac ttagaatgtg tctctaggca ttgttctgtg catatatcat 50821 ctcaatattc attatctgaa aattatgaat taggtacaaa gctcaaataa tttatttttt 50881 caggttagca agaacttttt tttttttttt ttctgagatg gagcattgct atggttgccc 50941 aggctggagt gcaatggcat gatccaggct cactgcaaca tctgcctccc aggttcaagc 51001 gattctcctg cctcagcctc ccaagtagct ggcattacag gcatgtgcca ccaccatgcc 51061 tggctaattt tctattttta gtagataggg ggtttcacca tgttggtcag gctgatctcg 51121 aactcctaac atcaggtgat ccaccctcct cggcctctga atgtactggg atcacaggcg 51181 tgagccacca cacccagcca agaatgtgaa ttttgtagaa ggatataacc catatttctc 51241 tgaccctaga gtccttagta tacctcccat accatgtggc tcatcctcct tacatacatt 51301 tcccatcttt caccctacct tttccttttt gtttcagctt ttcactgtgt gtcaaaatct 51361 agaaccttat ctcctacctg ctctgaaacc aacagcaagt tgacttccat tctaacccac 51421 attggcatta cactaattaa aatcgatact gagttctaaa atcatctggg attttgggga 51481 ctatgtctta cttcatactt ccttgagatt tcacattaaa tgttggtgtt cattaaaggt 51541 ccttcattta actttgtatt catcacactc ttggattcac agttatatct aaactcttat 51601 atatagcctg tataatccca attcccaagt ctgatttcta acctctgacc tccaacctca 51661 gtgccaaacc catatatcaa acaatgtact gggcttattt atatagatgt cctataggca 51721 cctcagactc agcatgggta tttcacttgt tatactaaaa ctgtttctct tccagtgttt 51781 tccattttag tcattagata gctacttgcc cattcaccaa ggtcacagat taaaatcatt 51841 tccctacctc taatcaacag ttcaattctg cttcaatttg tccctatcta ttaatcacca 51901 ctcttactgc ccagtcaggt cctcattgtt tcctgaacaa gagtagatgc tattctttcc 51961 actttaagac cttatcctgg ctggatgcgg tggctcaggc ttgtaaaccc agcactttgg 52021 gaggccgagg caggcagatc acttgaggtc aggagttcaa gaccagcctg accaacatgg 52081 tgaaacccca tctctactaa aaatacaaaa tcagccgggc gtgtggtgca tgcctgcagt 52141 cccagctatt caggtggctg aggcaggaga attgcttgaa cccaggaggc ggaggttgcg 52201 gtgagcctag attgcaccat tgcactctag cttgggcaat agggatgaaa ctccatctca 52261 gaagagaaaa gaaaaaaaga ccttattctg ttacacaaat cctctcaatg caatccatat 52321 agaataaaca tgtaaccaga tctcccaatg tgtaaaatca tttcaggtag aacagaatta 52381 aagtgaaaag ccaagtcttt ggaattaaca gacaaagttc aaataacagt cctcatggcc 52441 ttaagaattt acctaacatt ttttttagaa tcaattttct tatatatgaa ttggaaacat 52501 aattcctccc tcacaaacac attctaagat tttaaggaga tattgatgaa gtacatcatc 52561 tgtcattttt aacagttagt ggtagtgatt cacacagcac attatgatct gttcttgtat 52621 gttctgttcc attctgtatt cttgacctgg ttgtattctt tctgagctcc agatccacat 52681 atctaagtac atctttttgc attttacaag agtgcataca atacaatgta tccaagactg 52741 tatttctgat tttatcgtac cactaaactc acaaatgtgg ccctattctt gtgttcacga 52801 ctgacatcac cgtcatggtc caagtctgat aatagaaatg gcattgtcac tttcttccct 52861 actgcaacag aagcccagct atttgtctcc cattttctct acttctaaaa tacatttctt 52921 cactaagtga gaataatctt ttaaagacac aaatcaaacc atgccaccac ctttcttgaa 52981 ttattcaata tctttcgttg gcttccaggt tacagaaaaa taacttgtaa caaagtttaa 53041 aggtcattca tggctcctct ctaccctatt ttataacatt tccccttgtg atcagaatct 53101 caggcacatc atccatcttt ctatatacaa ataaagtcat atagtttgaa ctcacctctg 53161 gttactttta atcaaccaaa tgctgtaaaa tgcatttgta tcgctacgtg ttaagcagta 53221 gttgattctt ttcatttctt gttaatattc tattctttga ctataccgta atttatcaat 53281 tctactgttg gtaagcattt aagtggctac cggtttgagg tttttatgat tattgctgtc 53341 ataagcattt ctatacatgt ctttggatac acacatgcat gtgtttctga atatctaaaa 53401 atgtaattgc taggtaatag acttatcaag catccagcat ttgtggatac tattaaaggt 53461 tttccaaagg ggttatacta ttgtacagtg tcaccaacag agtttgagtt tctattgatc 53521 catatcacca ccaaaatttg aactgtcagt cttatctctt ctcttgtctc ttttttcctc 53581 ttttttttcc ttcccttccc ctctcttcgt ttcttttctc tcctcttctc ttctttcctc 53641 tcttcccttc cctttctctt tctcttccct atcccttctc ctctcctctc ccctcctttt 53701 ttctcctctc ctctccatta tttatttttc cttcttctcc tccatccctt ccatcctctc 53761 tcttcccctc ttccttcctt cctttctcca tttcttcctc ctctttccct caatccttcc 53821 ttttggatat gctcatgggt gtgtatttgt ctgccattgt ggcattattt gaattcagaa 53881 aagagtgaaa aactactggg atcttcattc tgggtctaat tccacatttt tttttaagaa 53941 cacactctgt aaaaatgttc tgtactagca tattcccagg aacttcgtta aatttaatct 54001 ggctgaatat ggtaaatcta ctttgcactt tgcattcttt ctttagtcat accataattt 54061 taaacattca aaatatttgt atataatatt tgattttatc tgtcattaaa atgttaacct 54121 taaaattcat gtttccagaa cctatttcaa taactggtaa ataaacacta ttcatttttt 54181 aaatattctt ttaatggata tttatttcaa tataataaaa aattagagtt ttattatagg 54241 aagaatttac caaaagaagg aggaagcaag caagtttaaa ctgcagcaat agttgtccat 54301 tccaacctct caaaattccc ttggagacaa aatctctaga ggcaaagaag aactttatat 54361 tgagtcaact tgttaaaaca tctgctttta gataagtttt cttagtataa agtgacagaa 54421 acaaataagt taaactctaa gatacattcc actatattag cctaaaacac ttctgcaaaa 54481 atgaaactag gaggatattt ttagaaacaa ctgctgaaag agatgcggtg gggagatatg 54541 cagaggagaa cagggtttct gagtcaagac acacatgaca gaacagccaa tctcagggca 54601 agttaaggga atagtggaat gaaggttcat ttttcattct cacaaactaa tgaaaccctg 54661 cttatcttaa accaacctgc tcactggagc agggaggaca ggaccagcat aaaaggcagg 54721 gcagagtcga ctgttgctta cactttcttc tgacataaca gtgttcacta gcaacctcaa 54781 acagacacca tggtgcatct gactcctgag gagaagactg ctgtcaatgc cctgtggggc 54841 aaagtgaacg tggatgcagt tggtggtgag gccctgggca ggttggtatc aaggttataa 54901 gagaggctca aggaggcaaa tggaaactgg gcatgtgtag acagagaaga ctcttgggtt 54961 tctgataggc actgactctc tgtcccttgg gctgttttcc taccctcaga ttactggtgg 55021 tctacccttg gacccagagg ttctttgagt cctttgggga tctgtcctct cctgatgctg 55081 ttatgggcaa ccctaaggtg aaggctcatg gcaagaaggt gctaggtgcc tttagtgatg 55141 gcctggctca cctggacaac ctcaagggca ctttttctca gctgagtgag ctgcactgtg 55201 acaagctgca cgtggatcct gagaacttca gggtgagtcc aggagatgct tcacttttct 55261 ctttttactt tctaatctta cattttggtt cttttaccta cctgctcttc tcccacattt 55321 ttgtcatttt actatatttt atcatttaat gcttctaaaa ttttgttaat tttttattta 55381 aatattctgc attttttcct tcctcacaat cttgctattt taaattattt aatatcctgt 55441 ctttctctcc caaccccctc ccttcatttt tccttctcta acaacaactc aaattatgca 55501 taccagctct cacctgctaa ttctgcactt agaataatcc ttttgtctct ccacatgggt 55561 atgggagagg ctccaactca aagatgagag gcatagaata ctgttttaga ggctataaat 55621 cattttacaa taaggaataa ttggaatttt ataaattctg tagtaaatgg aatggaaagg 55681 aaagtgaata tttgattatg aaagactagg cagttacact ggaggtgggg cagaagtcgt 55741 tgctaggaga cagcccatca tcacactgat taatcaatta atttgtatct attaatctgt 55801 ttatagtaat taatttgtat atgctatata cacatacaaa attaaaacta atttggaatt 55861 aatttgtata tagtattata cagcatatat agcatatatg tacatatata gactacatgc 55921 tagttaagta catagaggat gtgtgtgtat agatatatgt tatatgtatg cattcatata 55981 tgtacttatt tatgctgatg ggaataacct ggggatcagt tttgtctaag atttgggcag 56041 aaaaaaatgg gtgttggctc agtttctcag aagccagtct ttatttctct gttaaccata 56101 tgcatgtatc tgcctacctc ttctccgcag ctcttgggca atgtgctggt gtgtgtgctg 56161 gcccgcaact ttggcaagga attcacccca caaatgcagg ctgcctatca gaaggtggtg 56221 gctggtgtgg ctaatgccct ggctcacaag taccattgag atcctggact gtttcctgat 56281 aaccataaga agaccctatt tccctagatt ctattttctg aacttgggaa cacaatgcct 56341 acttcaaggg tatggcttct gcctaataaa gaatgttcag ctcaacttcc tgattaattt 56401 cacttatttc atttttttgt ccaggtgtgt aagaaggttc ctgaggctct acagataggg 56461 agcacttgtt tattttacaa agagtacatg ggaaaagaga aaagcaaggg aaccgtacaa 56521 ggcattaatg ggtgacactt ctacctccaa agagcagaaa ttatcaagaa ctcttgatac 56581 aaagataata ctggcactgc agaggttcta gggaagacct caaccctaag acatagcctc 56641 aagggtaata gctacgatta aactccaaca attactgaga aaataatgtg ctcaattaaa 56701 ggcataatga ttactcaaga caatgttatg ttgtctttct tcctccttcc tttgcctgca 56761 cattgtagcc cataatacta taccccatca agtgttcctg ctccaagaaa tagcttcctc 56821 ctcttacttg ccccagaaca tctctgtaaa gaatttcctc ttatcttccc atatttcagt 56881 caagattcat tgctcacgta ttacttgtga cctctcttga ccccagccac aataaacttc 56941 tctatactac ccaaaaaatc tttccaaacc ctccccgaca ccatattttt atatttttct 57001 tatttatttc atgcacacac acacactccg tgctttataa gcaattctgc ctattctcta 57061 ccttcttaca atgcctactg tgcctcatat taaattcatc aatgggcaga aagaaaatat 57121 ttattcaaga aaacagtgaa tgaatgaacg aatgagtaaa tgagtaaatg aaggaatgat 57181 tattccttgc tttagaactt ctggaattag aggacaatat taataatacc atcgcacagt 57241 gtttctttgt tgttaatgct acaacataca aagaggaagc atgcagtaaa caaccgaaca 57301 gttatttcct ttctgatcat aggagtaata tttttttcct tgagcacatt tttgccatag 57361 gtaaaattag aaggattttt agaactttct cagttgtata catttttaaa aatctgtatt 57421 atatgcatgt tgattaattt taaacttact tgaataccta aacagaatct gttgtttcct 57481 tgtgtttgaa agtgctttca cagtaactct gtctgtactg ccagaatata ctgacaatgt 57541 gttatagtta actgttttga tcacaacatt ttgaattgac tggcagcaga agctcttttt 57601 atatccatgt gttttcctta agtcattata catagtaggc atgagactct ttatactgaa 57661 taagatattt aggaaccact ggtttacata tcagaagcag agctactcag ggcattttgg 57721 ggaagatcac tttcacattc ctgagcatag ggaagttctc ataagagtaa gatattaaaa 57781 ggagatactt gtgtggtatt cgaaagacag taagagagat tgtagacctt atgatcttga 57841 tagggaaaac aaactacatt cctttctcca aaagtcaaaa aaaaagagca aatatagctt 57901 actatacctt ctattcctac accattagaa gtagtcagtg agtctaggca agatgttggc 57961 cctaaaaatc caaataccag agaattcatg agaacatcac ctggatggga catgtgccga 58021 gcaacacaat tactatatgc taggcattgc tatcttcata ttgaagatga ggaggtcaag 58081 agatgaaaaa agacttggca ccttgttgtt atattaaaat tatttgttag agtagagctt 58141 ttgtaagagt ctaggagtgt gggagctaaa tgatgataca catggacaca aagaatagat 58201 caacagacac ccaggcctac ttgagggttg agggtgggaa gagggagacg atgaaaaaga 58261 acctattggg tattaagttc atcactgagt gatgaaataa tctgtacatc aagacccagt 58321 gatatgcaat ttacctatat aacttgtaca tgtaccccca aatttaaaat aaagttaaaa 58381 caaagtatag gaatggaatt aattcctcaa gatttggctt taattttatt tgataattta 58441 tcaaatggtt gtttttcttt tctcactatg gcgttgcttt ataaactatg ttcagtatgt 58501 ctgaatgaaa gggtgtgtgt gtgtgtgaaa gagagggaga gaggaaggga agagaggacg 58561 taataatgtg aatttgagtt catgaaaatt tttcaataaa ataatttaat gtcaggagaa 58621 ttaagcctaa tagtctccta aatcatccat ctcttgagct tcagagcagt cctctgaatt 58681 aatgcctaca tgtttgtaaa gggtgttcag actgaagcca agattctacc tctaaagaga 58741 tgcaatctca aatttatctg aagactgtac ctctgctctc cataaattga caccatggcc 58801 cacttaatga ggttaaaaaa aagctaattc tgaatgaaaa tctgagccca gtggaggaaa 58861 tattaatgaa caaggtgcag actgaaatat aaattttctg taataattat gcatatactt 58921 tagcaaagtt ctgtctatgt tgactttatt gcttttggta agaaatacaa ctttttaaag 58981 tgaactaaac tatcctattt ccaaactatt ttgtgtgtgt gcggtttgtt tctatgggtt 59041 ctggttttct tggagcattt ttatttcatt ttaattaatt aattctgaga gctgctgagt 59101 tgtgtttact gagagattgt gtatctgcga gagaagtctg tagcaagtag ctagactgtg 59161 cttgacctag gaacatatac agtagattgc taaaatgtct cacttgggga attttagact 59221 aaacagtaga gcatgtataa aaatactcta gtcaagtgct gcttttgaaa caaatgataa 59281 aaccacactc ccatagatga gtgtcatgat tttcatggag gaagttaata ttcatcctct 59341 aagtataccc agactagggc cattctgata taaaacatta ggacttaaga aagattaata 59401 gactggagta aaggaaatgg acctctgtct ctctcgctgt ctcttttttg aggacttgtg 59461 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtt gtggtcagtg gggctggaat aaaagtagaa 59521 tagacctgca cctgctgtgg catccattca cagagtagaa gcaagctcac aatagtgaag 59581 atgtcagtaa gcttgaatag tttttcagga actttgaatg ctgatttaga tttgaaactg 59641 aggctctgac cataaccaaa tttgcactat ttattgcttc ttgaaactta tttgcctggt 59701 atgcctgggc ttttgatggt cttagtatag cttgcagcct tgtccctgca gggtattatg 59761 ggtaatagaa agaaaagtct gcgttacact ctagtcacac taagtaacta ccattggaaa 59821 agcaacccct gccttgaagc caggatgatg gtatctgcag cagttgccaa cacaagagaa 59881 ggatccatag ttcatcattt aaaaaagaaa acaaaataga aaaaggaaaa ctatttctga 59941 gcataagaag ttgtagggta agtctttaag aaggtgacaa tttctgccaa tcaggatttc 60001 aaagctcttg ctttgacaat tttggtcttt cagaatacta taaatataac ctatattata 60061 atttcataaa gtctgtgcat tttctttgac ccaggatatt tgcaaaagac atattcaaac 60121 ttccgcagaa cactttattt cacatataca tgcctcttat atcagggatg tgaaacaggg 60181 tcttgaaaac tgtctaaatc taaaacaatg ctaatgcagg tttaaattta ataaaataaa 60241 atccaaaatc taacagccaa gtcaaatctg tatgttttaa catttaaaat attttaaaga 60301 cgtcttttcc caggattcaa catgtgaaat cttttctcag ggatacacgt gtgcctagat 60361 cctcattgct ttagtttttt acagaggaat gaatataaaa agaaaatact taaattttat 60421 ccctcttacc tctataatca tacataggca taatttttta acctaggctc cagatagcca 60481 tagaagaacc aaacactttc tgcgtgtgtg agaataatca gagtgagatt ttttcacaag 60541 tacctgatga gggttgagac aggtagaaaa agtgagagat ctctatttat ttagcaataa 60601 tagagaaagc atttaagaga ataaagcaat ggaaataaga aatttgtaaa tttccttctg 60661 ataactagaa atagaggatc cagtttcttt tggttaacct aaattttatt tcattttatt 60721 gttttatttt attttatttt attttatttt gtgtaatcgt agtttcagag tgttagagct 60781 gaaaggaaga agtaggagaa acatgcaaag taaaagtata acactttcct tactaaaccg 60841 actgggtttc caggtagggg caggattcag gatgactgac agggccctta gggaacactg 60901 agaccctacg ctgacctcat aaatgcttgc tacctttgct gttttaatta catcttttaa 60961 tagcaggaag cagaactctg cacttcaaaa gtttttcctc acctgaggag ttaatttagt 61021 acaaggggaa aaagtacagg gggatgggag aaaggcgatc acgttgggaa gctatagaga 61081 aagaagagta aattttagta aaggaggttt aaacaaacaa aatataaaga gaaataggaa 61141 cttgaatcaa ggaaatgatt ttaaaacgca gtattcttag tggactagag gaaaaaaata 61201 atctgagcca agtagaagac cttttcccct cctaccccta ctttctaagt cacagaggct 61261 ttttgttccc ccagacactc ttgcagatta gtccaggcag aaacagttag atgtccccag 61321 ttaacctcct atttgacacc actgattacc ccattgatag tcacactttg ggttgtaagt 61381 gactttttat ttatttgtat ttttgactgc attaagaggt ctctagtttt ttatctcttg 61441 tttcccaaaa cctaataagt aactaatgca cagagcacat tgatttgtat ttattctatt 61501 tttagacata atttattagc atgcatgagc aaattaagaa aaacaacaac aaatgaatgc 61561 atatatatgt atatgtatgt gtgtatatat acacatatat atatatattt tttttctttt 61621 cttaccagaa ggttttaatc caaataagga gaagatatgc ttagaactga ggtagagttt 61681 tcatccattc tgtcctgtaa gtattttgca tattctggag acgcaggaag agatccatct 61741 acatatccca aagctgaatt atggtagaca aagctcttcc acttttagtg catcaatttc 61801 ttatttgtgt aataagaaaa ttgggaaaac gatcttcaat atgcttacca agctgtgatt 61861 ccaaatatta cgtaaataca cttgcaaagg aggatgtttt tagtagcaat ttgtactgat 61921 ggtatggggc caagagatat atcttagagg gagggctgag ggtttgaagt ccaactccta 61981 agccagtgcc agaagagcca aggacaggta cggctgtcat cacttagacc tcaccctgtg 62041 gagccacacc ctagggttgg ccaatctact cccaggagca gggagggcag gagccagggc 62101 tgggcataaa agtcagggca gagccatcta ttgcttacat ttgcttctga cacaactgtg 62161 ttcactagca acctcaaaca gacaccatgg tgcacctgac tcctgaggag aagtctgccg 62221 ttactgccct gtggggcaag gtgaacgtgg atgaagttgg tggtgaggcc ctgggcaggt 62281 tggtatcaag gttacaagac aggtttaagg agaccaatag aaactgggca tgtggagaca 62341 gagaagactc ttgggtttct gataggcact gactctctct gcctattggt ctattttccc 62401 acccttaggc tgctggtggt ctacccttgg acccagaggt tctttgagtc ctttggggat 62461 ctgtccactc ctgatgctgt tatgggcaac cctaaggtga aggctcatgg caagaaagtg 62521 ctcggtgcct ttagtgatgg cctggctcac ctggacaacc tcaagggcac ctttgccaca 62581 ctgagtgagc tgcactgtga caagctgcac gtggatcctg agaacttcag ggtgagtcta 62641 tgggaccctt gatgttttct ttccccttct tttctatggt taagttcatg tcataggaag 62701 gggagaagta acagggtaca gtttagaatg ggaaacagac gaatgattgc atcagtgtgg 62761 aagtctcagg atcgttttag tttcttttat ttgctgttca taacaattgt tttcttttgt 62821 ttaattcttg ctttcttttt ttttcttctc cgcaattttt actattatac ttaatgcctt 62881 aacattgtgt ataacaaaag gaaatatctc tgagatacat taagtaactt aaaaaaaaac 62941 tttacacagt ctgcctagta cattactatt tggaatatat gtgtgcttat ttgcatattc 63001 ataatctccc tactttattt tcttttattt ttaattgata cataatcatt atacatattt 63061 atgggttaaa gtgtaatgtt ttaatatgtg tacacatatt gaccaaatca gggtaatttt 63121 gcatttgtaa ttttaaaaaa tgctttcttc ttttaatata cttttttgtt tatcttattt 63181 ctaatacttt ccctaatctc tttctttcag ggcaataatg atacaatgta tcatgcctct 63241 ttgcaccatt ctaaagaata acagtgataa tttctgggtt aaggcaatag caatatttct 63301 gcatataaat atttctgcat ataaattgta actgatgtaa gaggtttcat attgctaata 63361 gcagctacaa tccagctacc attctgcttt tattttatgg ttgggataag gctggattat 63421 tctgagtcca agctaggccc ttttgctaat catgttcata cctcttatct tcctcccaca 63481 gctcctgggc aacgtgctgg tctgtgtgct ggcccatcac tttggcaaag aattcacccc 63541 accagtgcag gctgcctatc agaaagtggt ggctggtgtg gctaatgccc tggcccacaa 63601 gtatcactaa gctcgctttc ttgctgtcca atttctatta aaggttcctt tgttccctaa 63661 gtccaactac taaactgggg gatattatga agggccttga gcatctggat tctgcctaat 63721 aaaaaacatt tattttcatt gcaatgatgt atttaaatta tttctgaata ttttactaaa 63781 aagggaatgt gggaggtcag tgcatttaaa acataaagaa atgaagagct agttcaaacc 63841 ttgggaaaat acactatatc ttaaactcca tgaaagaagg tgaggctgca aacagctaat 63901 gcacattggc aacagccctg atgcctatgc cttattcatc cctcagaaaa ggattcaagt 63961 agaggcttga tttggaggtt aaagttttgc tatgctgtat tttacattac ttattgtttt 64021 agctgtcctc atgaatgtct tttcactacc catttgctta tcctgcatct ctcagccttg 64081 actccactca gttctcttgc ttagagatac cacctttccc ctgaagtgtt ccttccatgt 64141 tttacggcga gatggtttct cctcgcctgg ccactcagcc ttagttgtct ctgttgtctt 64201 atagaggtct acttgaagaa ggaaaaacag ggggcatggt ttgactgtcc tgtgagccct 64261 tcttccctgc ctcccccact cacagtgacc cggaatctgc agtgctagtc tcccggaact 64321 atcactcttt cacagtctgc tttggaagga ctgggcttag tatgaaaagt taggactgag 64381 aagaatttga aagggggctt tttgtagctt gatattcact actgtcttat taccctatca 64441 taggcccacc ccaaatggaa gtcccattct tcctcaggat gtttaagatt agcattcagg 64501 aagagatcag aggtctgctg gctcccttat catgtccctt atggtgcttc tggctctgca 64561 gttattagca tagtgttacc atcaaccacc ttaacttcat ttttcttatt caatacctag 64621 gtaggtagat gctagattct ggaaataaaa tatgagtctc aagtggtcct tgtcctctct 64681 cccagtcaaa ttctgaatct agttggcaag attctgaaat caaggcatat aatcagtaat 64741 aagtgatgat agaagggtat atagaagaat tttattatat gagagggtga aacctaaaat 64801 gaaatgaaat cagacccttg tcttacacca taaacaaaaa taaatttgaa tgggttaaag 64861 aattaaacta agacctaaaa ccataaaaat ttttaaagaa atcaaaagaa gaaaattcta 64921 atattcatgt tgcagccgtt ttttgaattt gatatgagaa gcaaaggcaa caaaaggaaa 64981 aataaagaag tgaggctaca tcaaactaaa aaatttccac acaaaaaaga aaacaatgaa 65041 caaatgaaag gtgaaccatg aaatggcata tttgcaaacc aaatatttct taaatatttt 65101 ggttaatatc caaaatatat aagaaacaca gatgattcaa taacaaacaa aaaattaaaa 65161 ataggaaaat aaaaaaatta aaaagaagaa aatcctgcca tttatgcgag aattgatgaa 65221 cctggaggat gtaaaactaa gaaaaataag cctgacacaa aaagacaaat actacacaac 65281 cttgctcata tgtgaaacat aaaaaagtca ctctcatgga aacagacagt agaggtatgg 65341 tttccagggg ttgggggtgg gagaatcagg aaactattac tcaaagggta taaaatttca 65401 gttatgtggg atgaataaat tctagatatc taatgtacag catcgtgact gtagttaatt 65461 gtactgtaag tatatttaaa atttgcaaag agagtagatt tttttgtttt tttagatgga 65521 gttttgctct tgttgtccag gctggagtgc aatggcaaga tcttggctca ctgcaacctc 65581 cgcctcctgg gttcaagcaa atctcctgcc tcagcctccc gagtagctgg gattacaggc 65641 atgcgacacc atgcccagct aattttgtat ttttagtaga gacggggttt ctccatgttg 65701 gtcaggctga tccgcctcct cggccaccaa agggctggga ttacaggcgt gaccaccggg 65761 cctggccgag agtagatctt aaaagcattt accacaagaa aaaggtaact atgtgagata 65821 atgggtatgt taattagctt gattgtggta atcatttcac aaggtataca tatattaaaa 65881 catcatgttg tacaccttaa atatatacaa tttttatttg tgaatgatac ctcaataaag 65941 ttgaagaata ataaaaaaga atagacatca catgaattaa aaaactaaaa aataaaaaaa 66001 tgcatcttga tgattagaat tgcattcttg atttttcaga tacaaatatc catttgactg 66061 tttactcttt tccaaaacaa tacaataaat tttagcactt tatcttcatt ttccccttcc 66121 caatctataa ttttatatat atatatttta gatattttgt atagttttac tccctagatt 66181 ttctagtgtt attattaaat agtgaagaaa tgtttacact tatgtacaaa atgttttgca 66241 tgcttttctt catttctaac attctctcta agtttattct attttttcct gattatcctt 66301 aatattatct ctttctgctg gaaatatatt gttacttttg gtttatctaa aaatggcttc 66361 attttcttca ttctaaaatc atgttaaatt aataccactc atgtgtaagt aagatagtgg 66421 aataaataga aatccaaaaa ctaaatctca caaaatataa taatgtgata tataaaaata 66481 tagcttttaa atttagcttg gaaataaaaa acaaacagta attgaacaac tatacttttt 66541 gaaaagagta aagtgaaatg cttaactgca tataccacaa tcgattacac aattaggtgt 66601 gaaggtaaaa ttcagtcacg aaaaaactag aataaaaata tgggaagaca tgtatataat 66661 cttagagata acagtgttat ttaattatca acccaaagta gaaactatca agggagaaat 66721 aaattcagtc aacaataaaa gcatttaaga agttattcta ggctgggagc ggtggctcac 66781 acctgcaatt gcagcacttt gggaggccta gacaggcgga tcacgacgtc aggagttcaa 66841 gatcagcctg gccaacatag tgaaacctca tcgctactaa aaatataaaa acttagcctg 66901 gcgtggtggc aggcatgtgt aatcccagca atttgggagg ctgaggcagg agaatcgctt 66961 gatcctggga ggcagaggtt gcagtgagcc aagattgtgc cactgcattc cagcccaggt 67021 gacagcatga gactccgtca caaaaaaaaa agaaaaaaaa gggggggggg ggcggtggag 67081 ccaagatgac cgaataggaa cagctccagt ctatagctcc catcgtgagt gacgcagaag 67141 acgggtgatt tctgcatttc caactgaggt accaggttca tctcacaggg aagtgccagg 67201 cagtgggtgc aggacagtag tgcagtgcac tgtgcatgag ccgaagcagg gcgaggcatc 67261 acctcacccg ggaagcacaa ggggtcaggg aattcccttt cctagtcaaa gaaaagggtg 67321 acagatggca cctggaaaat cgggtcactc ccgccctaat actgcgctct tccaacaagc 67381 ttaacaaatg gcacaccagg agattatatc ccatgcctgg ctcagagggt cctacgccca 67441 tggagcctcg ctcattgcta gcacagcagt ctgaggtcaa actgcaaggt ggcagtgagg 67501 ctgggggagg ggtgcccacc attgtccagg cttgagcagg taaacaaagc cgcctggaag 67561 ctcgaactgg gtggagccca ccacagctca aggaggcctg cctgcctctg taggctccac 67621 ctctaggggc agggcacaga caaacaaaag acaacaagaa cctctgcaga cttaaatgtc 67681 cctgtctgac agctttgaag agagtagtgg ttctcccagc acatagcttc agatctgaga 67741 acaggcagac tgcctcctca agtgggtccc tgacccccga gtagcctaac tgggaggcat 67801 cccccagtag ggcggactga cacctcacat ggctggtact cctctaagac aaaacttcca 67861 gaggaatgat caggcagcag catttgcggt tcaccaatat ccactgttct gcagccaccg 67921 ctgctgatac ccaggaaaac agcatctgga gtggacctcc agtaaactcc aacagacctg 67981 cagctgaggg tcctgactgt tagaaggaaa actaacaaac agaaaggaca tccacaccaa 68041 aaacccatct gtacatcacc atcatcaaag accaaaggta gataaaacca taaagatggg 68101 gaaaaagcag agcagaaaaa ctggacactc taaaaatgag agtgcctctc cttctccaaa 68161 gtaacgcagc tcctcaccag caatggaaca aagctgggca gagaatgact ttgacgagtt 68221 gagagaggaa ggcttcagaa gatcaaacta ctccaagcta aaggaggaag ttcgaacaaa 68281 cggcaaagaa gtaaaaaact ttgaaaaaaa attagatgaa tggataacta gaataaccaa 68341 tgcacagaag tccttaaagg acctgatgga gctgaaaacc aaggcaggag aactacgtga 68401 caaatacaca agcctcagta accgatgaga tcaactggaa gaaagggtat caatgacgga 68461 agatgaaatg aatgaaatga agcatgaaga gaagtttaga gaaaaaagaa taaaaagaaa 68521 cgaacaaagc ctccaagaaa tatgggacta tgtgaaaaga ccaaatctac atctaattgg 68581 tgtagctgaa agtgatgggg agaatggaac caagttggaa aacactctgc aggatattat 68641 ccaggagaac ttccccaatc tagcaaggca gcccaaattc acattcagga aatacagaga 68701 acgccacaaa gatactccta gagaaaagca actccaagac acataactga cagattcacc 68761 aaagttgaaa tgaaggaaaa aatgttaagg gcagccagag agaaaggtcg ggttacccac 68821 aaagggaagc ccatcagact aacagctgat ctatcggcag aaactctaca agccagaaga 68881 aagtgggggc caatattcaa cattgttaaa gaaaagaatt ttcggcccag aatttcatat 68941 ccagccaaac taagcttcat aagcattgga gaaataaaat cctttacaga caagcaaatg 69001 ctgagagatt ttgtcaccac caggcctgcc ctacaagagc tcctgaagga agcactaaac 69061 atggaaagga acaactagta tcagccactg caaaaacatg ccaaattgta aacgaccatc 69121 aaggctagga agaaactgca tcaaggagca aaataaccag ctaacatcat aatgacagga 69181 tcaaattcat acataacaat actcacctta aatgtaaata ggctaaatgc tccaattaaa 69241 agacacagac tggcaaattg gataaggagt caagacccat ctgtcgttat gtattcagga 69301 aacccatctc acgtgcagag acacacatag gctcgaaata aaaggatgga ggaatatcta 69361 ccaagcaaat ggaaaacaaa aaaaggcagg ggttgcaatc ctagtctctg ataaaacaga 69421 ttttaaacca acaaagatca aaagagacaa agaaggccat tacataatgg caaagggatc 69481 tattcaagaa gaagaactaa ctatactaaa tatatatgca cccaatacag gagcacccag 69541 attcataaaa caagtcctga gtgacctaca aagagactta gatgcccaca caataataat 69601 gggagacttt aacaccccac tgtcaacatt agacagatca acgagacaga aagttaacaa 69661 ggatatccag gaattggact cagctctgca ccaagcagac ctaatagaca tctacagaac 69721 tctccacccc aaatcaacag aatatacatt cttttcagca ccacaccaca cctattccaa 69781 aactgaccac atagttggaa gtaaagctct cctcagcaaa tgtaaaagaa cagaaactat 69841 aacaaactgt ctctcagacc acagtgcaat caaactagaa ctcaggatta agaaactcac 69901 tcaaaaccac tcagctacat ggaaactgaa cagcctgctc ctgaatgact actgggtaca 69961 taacaaaatg aaggcagaaa taaagatgtt ctttgaaaca acgagaacaa agacacaaca 70021 caccagaatc tctgagacac attcaaagca gtgtgtagag ggaaatttat agcactaaat 70081 gcccacaagg gaaagcagga aagatctaaa attgacaccc taacatcaca attaaaaaac 70141 tagagaagca ggagcaaaca cattcaaaag ctaacagaag acaagaaata actaagatca 70201 gagcagaagt gaagaagata gagacacaaa aaacccttca aaaaaatcaa tgaatccaga 70261 agctgttttt ttgaaaagat caacaaaatt gatagactgc tagcaagact aataaagaag 70321 aaaggggaga agaatcaaat agacgcaata aaaaatgaca cggggtatca ccactgatcc 70381 cacagaaata caaactaccg tcagagaata ctataaacac ctctacgcaa ataaactaga 70441 aaatctagaa gaaatggata aattcctcga cacatacact ctgccaagac taaaccagga 70501 agaagttgta tctctgaata gaccaataac aggctctgaa attgaggcaa taattaatag 70561 cttatcaacc aaaaaaagtc cgggaccagt aggattcata gccgaattct accagaggta 70621 caaggaggag ctggtaccat tccttctgaa actattccaa tcaatagaaa aagagggaat 70681 cctccctaac tcattttatg aggccagcat catcctgata ccaaagcctg acagagacac 70741 aacaaaaaaa gagaatgtta caccaatatc cttgatgaac atcgatgcaa aaatcctcaa 70801 taaaatactg gcaaactgaa tccagcagca catcaaaaag cttatcctcc atgatcaagt 70861 gggcttcatc cctgccatgc aaggctggtt caacatacga aatcaataaa cataatccag 70921 catataaaca gaaccaaaga cacaaaccat atgattatct caatagatgc agaaaaggcc 70981 tttgacaaaa ttcaacaatg cttcatgcta aaaactctca ataaattagg tattgatggg 71041 acatatctca aaataataag agctatctat gacaaaccca cagccaatat catactgagt 71101 ggacaaaaac tggaagcatt ccctttgaaa actggcacaa ggcagggatg ccctctctca 71161 ccactcctat tcaacatagt gttggaagtt ctggccaggg caatcaggca ggagaaggaa 71221 ataaagggca ttcaattagg aaaagaggaa ggtgaaattg tccctgtttg cagatgacat 71281 gattgtatat ctagaaaacc ccattgtctc agcccaaaat ctccttaagc tgataagcaa 71341 cttcagcaaa gtctcaggat ataaaatcag tgtgcaaaaa tcacaagtat tcctatgcac 71401 caataacaga caaacagaga gccaaatcat gagtgaactc ccattcacaa ttgcttcaaa 71461 gagaataaaa tacctaggaa tccaacttac aagggatgtg aaggacctct tcaaggagaa 71521 ctacaaacca ctgctcaatg aaataaaaga ggatacaaac aaatggaaga acattccatg 71581 cttatgggta ggaagaatca tatcgtgaaa atggtcatac tgcccaaggt aatttataga 71641 ttcaatgcca tccccatcaa gctaccaatg actttcttca cagaactgga aaaaactact 71701 ttaaagttca tatggaatca aaaaagagcc cacatcacca aggcaatcct aagccaaaag 71761 aacaaagctg gaggcatcac gctacctgac ttcaaactat actacaatgc tacggtaacc 71821 aaaacagcat ggtactggta ccaaaacaga gatctagacc aatggaacag aacagagccc 71881 tcagaaataa tgccgcatat ctacaactat ccgatctttg acaaacctga gagaaacaag 71941 caatggggaa aggattccct atttaataaa tggtgctggg aaaactggct agccatatgt 72001 agaaagctga aactggatcc ttccttacac cttatacaaa aattaattca agatggatta 72061 aagacttaaa cattagacct aaaaccataa aaaccctaga aaaaaaccta ggcaatacca 72121 ttcaggacat aggcatgggc aaggacttca tgtctaaaac accaaaacga atggcaacaa 72181 aagacaaaat ggacaaacgg gatctaatta aactaaagag cttctgcaca gctaaagaaa 72241 ctaccatcag agtgaacagg caacctacaa aatgggagaa aatttttgca atctactcat 72301 ctgacaaagg gctaatatcc agaatctaca atgaactcaa acaaatttac aagaaaaaac 72361 aaacaacccc atcaaaaagt gggcaaagga tatgaacaga cacttctcaa aagaagacat 72421 ttatgtaatc aaaaaacaca tgaaaaaatg ctcatcatca ctagccatca gagaaatgca 72481 aatcaaaacc acaatgagat accatctcac accagttaga atggcgatca ttaaaaagtc 72541 aggaaacaac aggtgctgga gaggatgtgg agaaacagga acaactttta cactgttggt 72601 gggactgtaa actagttcaa ccattgcgga agtcagtgtg gcaattcctc aggaatctag 72661 aactagaaat accatttgac ccagccatcc cattactggg tagataccca aaggattata 72721 aatcatgctg ctataaagac acatgcacac gtatgtttat tgcagcacta ttcacaatag 72781 caaagacttg gaaccaaccc aaatgtccaa caacgataga ttggattaag aaaatgtggc 72841 acatatacac catggaatac tatgcagcca taaaaaatga tgagttcatg tcctttgtag 72901 ggacatggat gaagctggaa actatcattc tcagcaaact atcacaagga caataaacca 72961 aacaccgcat gttctcactc ataggtggga attgaacaat gagaacacat ggacacatga 73021 agaggaacat cacactctgg ggactgttat ggggtggggg gcaggggcag ggatagcact 73081 aggagatata cctaatgcta aatgacgagt taatgggtgc agcacaccaa catggcacat 73141 gtatacatat ataacaaacc tgccgttgtg cacatgtacc ctaaaacttg aagtataata 73201 ataaaaaaaa gttatcctat taaaactgat ctcacacatc cgtagagcca ttatcaagtc 73261 tttctctttg aaacagacag aaatttagtg ttttctcagt cagttaac //