HIV-1 gp120 envelope glycoprotein complexed with CD4 antigen

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Now let's look at the structure of the gp120 of HIV. In this image the alpha helices are shown in dark pink and the beta sheets in yellow-orange. The connecting segments are in white. The glycoprotein shown in the image below is not complete since the N-terminus is missing up to residue 89 . The protein chain is folded into an inner and an outer domain which are linked by an anti-parallel four-stranded bridging . This microdomain is also in contact with the and the . To see this rotate the molecule using the mouse or here . Also found extending from the outer domain is a region consisting of the beta 15 sheet and the alpha 3 helix . This is also in contact with the CD4 molecule.

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The paper in Nature describing this is here - Protein database information is here - Go back to the previous page here.

© Richard Hunt, University of South Carolina School of Medicine.
Ported to Jmol by Angel Herráez, Universidad de Alcalá, Spain.