β-oxidación de ácidos grasos insaturados

Clave:	aDH	eH	hDH	T	eI	dR
	acil-CoA deshidrogenasa	enoil-CoA hidratasa	β-hidroxiacil-CoA deshidrogenasa	tiolasa	enoil-CoA isomerasa	2,4-dienoil-CoA reductasa
					de Δ^3c a Δ^2t (cis) a (trans)	de Δ^2t,4c a Δ^3c y gasta 1 NADPH

Ejemplo nº 1: linoleico

	18:2Δ^9c,12c		18:2ω−6
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	16:2Δ^7c,10c		16:2ω−6
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	14:2Δ^5c,8c		14:2ω−6
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	12:2Δ^3c,6c		12:2ω−6
eI
	12:2Δ^2t,6c
eH+hDH+T		AcCoA + NADH
	10:1Δ^4c		10:1ω−6
aDH		FADH₂
	10:2Δ^2t,4c
dR		NADPH
	10:1Δ^3c
eI
	10:1Δ^2t
eH+hDH+T		AcCoA + NADH
	8:0
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	6:0
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	4:0
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	AcCoA
balance global:	9 AcCoA	+ 7 FADH₂ + (8-1) NADH

Ejemplo nº 2: alfa-linolénico

	18:3Δ^9c,12c,15c		18:3ω−3
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	16:3Δ^7c,10c,13c		16:3ω−3
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	14:3Δ^5c,8c,11c		14:3ω−3
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	12:3Δ^3c,6c,9c		12:3ω−3
eI
	12:3Δ^2t,6c,9c
eH+hDH+T		AcCoA + NADH
	10:2Δ^4c,7c		10:2ω−3
aDH		FADH₂
	10:3Δ^2t,4c,7c
dR		NADPH
	10:2Δ^3c,7c
eI
	10:2Δ^2t,7c
eH+hDH+T		AcCoA + NADH
	8:1Δ^5c		8:1ω−3
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	6:1Δ^3c		6:1ω−3
eI
	6:1Δ^2t
eH+hDH+T		AcCoA + NADH
	4:0
aDH+eH+hDH+T		AcCoA + FADH₂ + NADH
	AcCoA
balance global:	9 AcCoA	+ 6 FADH₂ + (8-1) NADH

Nota: por simplificar el balance, se ha considerado que el gasto de 1 NADPH equivale a la formación de 1 NADH menos.